Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | TDO2 | P48775 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15829428 | 0.83 | HRH3 (0.48) | HRH3CYP2D6TDO2IDO1RORC | |
| SCHEMBL16220941 | 0.80 | HRH3 (0.46) | HRH3CYP2D6RORCALDH1A1NPC1 | |
| SCHEMBL19633902 | 0.80 | HRH3 (0.46) | HRH3CYP2D6RORCALDH1A1L3MBTL1 | |
| SCHEMBL16217399 | 0.80 | HRH3 (0.46) | HRH3CYP2D6TDO2IDO1RORC | |
| SCHEMBL4883637 | 0.70 | PDE4A (0.49) | HRH3CYP2D6RORCALDH1A1NPC1 | |
| SCHEMBL15829990 | 0.69 | FPR2 (0.59) | HRH3CYP2D6RORCALDH1A1MAPT | |
| SCHEMBL16038107 | 0.69 | HRH3 (0.56) | HRH3CYP2D6RORCMAPTSMN1; SMN2 | |
| SCHEMBL15261932 | 0.69 | HRH3 (0.50) | HRH3CYP2D6RORCNPC1RAB9A | |
| SCHEMBL15772392 | 0.68 | HRH3 (0.50) | HRH3CYP2D6RORCMAPTSMN1; SMN2 | |
| SCHEMBL18183745 | 0.68 | HRH3 (0.55) | HRH3CYP2D6RORCMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219465-A2 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme Inc (US) | 2023-08-02 | — | — | EP | disclosed |
| EP-3498701-A1 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme Inc (US) | 2019-06-19 | — | — | EP | disclosed |