Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.74 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | NT5E | P21589 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | TYK2 | P29597 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | STAT3 | P40763 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6815524 | 0.95 | NAMPT (0.71) | NAMPTCYP17A1KDM4EL3MBTL1GAA | |
| SCHEMBL21661749 | 0.91 | NAMPT (0.72) | NAMPTCYP17A1KMT2ALMNAPOLB | |
| SCHEMBL334709 | 0.89 | CYP17A1 (0.68) | NAMPTCYP17A1KDM4EL3MBTL1POLB | |
| SCHEMBL24003848 | 0.88 | NAMPT (0.66) | NAMPTCYP17A1KDM4EL3MBTL1GAA | |
| SCHEMBL24004009 | 0.87 | NAMPT (0.65) | NAMPTCYP17A1KDM4EL3MBTL1NT5E | |
| SCHEMBL8770870 | 0.86 | NAMPT (0.67) | NAMPTCYP17A1KMT2ALMNAPOLB | |
| SCHEMBL8773493 | 0.86 | NAMPT (0.67) | NAMPTCYP17A1KMT2APOLBMAPT | |
| SCHEMBL22461360 | 0.85 | NAMPT (0.65) | NAMPTCYP17A1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL22461618 | 0.85 | NAMPT (0.65) | NAMPTCYP17A1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL17526122 | 0.85 | NAMPT (0.73) | NAMPTKDM4EKMT2ALMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10723724-B2 | Compounds for treating degenerative diseases of central nervous system or brain tumor, and uses thereof | SUN YAT-SEN UNIVERSITY (CN) | 2020-07-28 | — | — | US | disclosed |
| US-20190202817-A1 | COMPOUNDS FOR TREATING DEGENERATIVE DISEASES OF CENTRAL NERVOUS SYSTEM OR BRAIN TUMOR, AND USES THEREOF | SUN YAT-SEN UNIVERSITY (CN) | 2019-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190202817-A1 | COMPOUNDS FOR TREATING DEGENERATIVE DISEASES OF CENTRAL NERVOUS SYSTEM OR BRAIN TUMOR, AND USES THEREOF | SGK1, SGK3, SGK2 | NAMPT 1724/4885CYP17A1 1429/4885KDM4E 3951/4885 |
| US-10723724-B2 | Compounds for treating degenerative diseases of central nervous system or brain tumor, and uses thereof | SGK1, SGK3, SGK2 | NAMPT 1724/4885CYP17A1 1429/4885KDM4E 3951/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.