Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 1.00 |
| ▸ | PDGFRB | P09619 | 5/20 | 1.00 |
| ▸ | FGFR1 | P11362 | 4/20 | 1.00 |
| ▸ | EGFR | P00533 | 3/20 | 1.00 |
| ▸ | KIT | P10721 | 2/20 | 1.00 |
| ▸ | NEK2 | P51955 | 2/20 | 1.00 |
| ▸ | MELK | Q14680 | 2/20 | 1.00 |
| ▸ | PRKAA1 | Q13131 | 14/20 | 0.87 |
| ▸ | PRKAA2 | P54646 | 13/20 | 0.87 |
| ▸ | FLT3 | P36888 | 4/20 | 0.81 |
| ▸ | PLK4 | O00444 | 2/20 | 0.81 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.81 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.81 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.81 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.81 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.81 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.81 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.81 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.81 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Su-11652 SCHEMBL21067494 | 1.00 | KDR (1.00) | KDRPDGFRBFGFR1EGFRKIT | |
| Su-11652 SCHEMBL29366350 | 1.00 | KDR (1.00) | KDRPDGFRBFGFR1EGFRKIT | |
| Su-11652 SCHEMBL2212420 | 1.00 | KDR (1.00) | KDRPDGFRBFGFR1EGFRKIT | |
| SCHEMBL29857040 | 0.93 | PRKAA1 (1.00) | KDRPDGFRBFGFR1EGFRKIT | |
| SCHEMBL31672439 | 0.91 | KDR (0.84) | KDRPDGFRBFGFR1EGFRKIT | |
| SCHEMBL15202704 | 0.91 | KDR (0.84) | KDRPDGFRBFGFR1EGFRKIT | |
| SCHEMBL2113942 | 0.91 | KDR (0.84) | KDRPDGFRBFGFR1EGFRKIT | |
| SCHEMBL13755223 | 0.91 | KDR (0.84) | KDRPDGFRBFGFR1EGFRKIT | |
| SCHEMBL22486002 | 0.90 | KDR (0.82) | KDRPDGFRBFGFR1EGFRKIT | |
| SCHEMBL18651190 | 0.90 | KDR (0.85) | KDRPDGFRBFGFR1EGFRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230355581-A1 | METHODS OF TREATMENT FOR MELANOMA | The Board of Regents of the Unversity of Texas System (US) | 2023-11-09 | — | — | US | claimed |
| WO-2022006512-A9 | METHODS OF TREATMENT FOR MELANOMA | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2022-02-24 | — | — | WO | claimed |
| EP-4662319-A2 | PERSONALIZED CRISPR PROFILING FOR CANCER | Integrate Bioscience LLC (US) | 2025-12-17 | — | — | EP | disclosed |
| WO-2024168301-A2 | PERSONALIZED CRISPR PROFILING FOR CANCER | FUNCTION ONCOLOGY, INC. (US) | 2024-08-15 | — | — | WO | disclosed |
| US-20230355581-A1 | METHODS OF TREATMENT FOR MELANOMA | The Board of Regents of the Unversity of Texas System (US) | 2023-11-09 | — | — | US | disclosed |
| WO-2022006512-A9 | METHODS OF TREATMENT FOR MELANOMA | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2022-02-24 | — | — | WO | disclosed |
| US-20220054499-A1 | SMALL MOLECULES FOR MOUSE SATELLITE CELL PROLIFERATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2022-02-24 | — | — | US | disclosed |
| US-20210317107-A1 | INDOLINONE DERIVATIVES AS INHIBITORS OF MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2021-10-14 | — | — | US | disclosed |
| US-11026952-B2 | Small molecules for mouse satellite cell proliferation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2021-06-08 | — | — | US | disclosed |
| US-10981896-B2 | Indolinone derivatives as inhibitors of maternal embryonic leucine zipper kinase | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2021-04-20 | — | — | US | disclosed |
| US-20180000771-A1 | AGENT FOR PREVENTING AND/OR TREATING AMYOTROPHIC LATERAL SCLEROSIS | KYOTO UNIVERSITY (JP) | 2018-01-04 | — | — | US | disclosed |
| CN-1736486-A | Anticancer implantation agent | KONG QINGZHONG (CN) | 2006-02-22 | — | — | CN | disclosed |
| CN-1733304-A | Anticancer medicine composition containing blood vessel inhibitor | KONG QINGZHONG (CN) | 2006-02-15 | — | — | CN | disclosed |
| CN-1733305-A | Anticancer implantation agent | KONG QINGZHONG (CN) | 2006-02-15 | — | — | CN | disclosed |
| CN-1733306-A | Anticancer implantation agent containing blood vessel inhibitor and guanine similarities | KONG QINGZHONG (CN) | 2006-02-15 | — | — | CN | disclosed |
| CN-1733303-A | Anticancer implantation agent containing blood vessel inhibitor | KONG QINGZHONG (CN) | 2006-02-15 | — | — | CN | disclosed |
| CN-1733301-A | Anticancer implantation agent | KONG QINGZHONG (CN) | 2006-02-15 | — | — | CN | disclosed |
| CN-1733300-A | Anticancer implantation agent | KONG QINGZHONG (CN) | 2006-02-15 | — | — | CN | disclosed |
| CN-1733302-A | Anticancer implantation agent | KONG QINGZHONG (CN) | 2006-02-15 | — | — | CN | disclosed |
| CN-1686546-A | Anti entity tumour medicinal composition containing blood vessel inhibitor | SHANDONG LANJIN BIOLOG ENGINEE (CN) | 2005-10-26 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11026952-B2 | Small molecules for mouse satellite cell proliferation | MKI67, MYLK2, MYH2 | KDR 2116/4885PDGFRB 197/4885FGFR1 475/4885 |
| US-20220054499-A1 | SMALL MOLECULES FOR MOUSE SATELLITE CELL PROLIFERATION | MKI67, MYLK2, MYH2 | KDR 2116/4885PDGFRB 197/4885FGFR1 475/4885 |
| US-20180000771-A1 | AGENT FOR PREVENTING AND/OR TREATING AMYOTROPHIC LATERAL SCLEROSIS | WEE2, WEE1, ERBB2 | KDR 648/4885PDGFRB 40/4885FGFR1 48/4885 |
| US-20210317107-A1 | INDOLINONE DERIVATIVES AS INHIBITORS OF MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE | MELK, HIPK1, HIPK3 | KDR 2311/4885PDGFRB 2459/4885FGFR1 2024/4885 |
| US-10981896-B2 | Indolinone derivatives as inhibitors of maternal embryonic leucine zipper kinase | MELK, HIPK1, HIPK3 | KDR 2062/4885PDGFRB 2080/4885FGFR1 1894/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.