MYH2

Myosin-2 · Q9UKX2 · MYH2 on Sugi Atlas →

620 patent compounds predicted against MYH2, 446 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL19200973 SCHEMBL19200973 1.00 1/20
SCHEMBL29695613 SCHEMBL29695613 1.00 1/20
SCHEMBL29695618 SCHEMBL29695618 1.00 1/20
SCHEMBL29695657 SCHEMBL29695657 1.00 1/20
SCHEMBL21067621 SCHEMBL21067621 0.71 1/20
SCHEMBL18214930 SCHEMBL18214930 0.69 1/20
SCHEMBL21067295 SCHEMBL21067295 0.69 1/20
SCHEMBL25247212 SCHEMBL25247212 0.67 1/20
SCHEMBL23909334 SCHEMBL23909334 0.66 1/20
SCHEMBL23909337 SCHEMBL23909337 0.66 1/20
SCHEMBL23917036 SCHEMBL23917036 0.66 1/20
SCHEMBL25857172 SCHEMBL25857172 0.66 1/20
SCHEMBL23136657 SCHEMBL23136657 0.65 1/20
SCHEMBL19200456 SCHEMBL19200456 0.65 1/20
SCHEMBL23917202 SCHEMBL23917202 0.65 1/20
SCHEMBL29424218 SCHEMBL29424218 0.65 1/20
SCHEMBL23000093 SCHEMBL23000093 0.64 1/20
SCHEMBL23136659 SCHEMBL23136659 0.64 1/20
SCHEMBL26214101 SCHEMBL26214101 0.64 1/20
SCHEMBL25856865 SCHEMBL25856865 0.62 1/20

Clinical trials — most relevant to MYH2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Lifestyle and Pharmacological Interventions in Hypertrophic Cardiomyopathy PHASE2/PHASE3COMPLETED
The Effect of Neuromuscular Electrical Stimulation (NMES) PHASE2COMPLETED
Sacubitril/Valsartan vs Lifestyle in Hypertrophic Cardiomyopathy PHASE2COMPLETED
COSMIC-HF - Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure PHASE2COMPLETED
Evaluating MED2005 & Nitrostat Bioavailability PHASE1COMPLETED
Autologous Cultured Myoblasts (BioWhittaker) Transplanted Via Myocardial Injection PHASE1UNKNOWN
Transcutaneous Functional Magnetic Muscle Stimulation in Critically Ill nanUNKNOWN
Phenotypic and Genotypic Identification and Characterization of MYH9-related Constitutional Thrombocytopenia nanCOMPLETED
Mapping of End Stage Renal Disease Genetic Susceptibility in African Americans by Admixture Linkage Disequilibrium nanCOMPLETED
Characteristics of Nondystrophic Myotonias nanCOMPLETED
Precision Medicine for Nociception, Sngception and Proprioception. nanRECRUITING
Hypertrophic Cardiomyopathy Registry, Biobank and Imaging Data Repository nanENROLLING_BY_INVITATION
HIF-1α Stabilization As a Novel Therapeutical Approach for Sarcopenia. nanRECRUITING
Improvement of DIAgnostic and Phenotype-genotype Correlation Studies in Patients With MYOpathy Suspected of TITinopathy nanUNKNOWN
The Muscle in Cerebral Palsy; Sarcomere Length in Vivo and Microscopic Characterization of Biopsies. nanRECRUITING
Genes Mutation Pentalogy of Cantrell nanWITHDRAWN
Multicenter Study of Immunoadsorption in Dilated Cardiomyopathy nanCOMPLETED
Molecular and Genetic Studies of Congenital Myopathies nanRECRUITING
Natural History Study for Patients With Nemaline Myopathy in Belgium nanNOT_YET_RECRUITING
Precision Pharmacogenetics and Genotype Class Based Prediction of Mavacamten Response in Obstructive Hypertrophic Cardiomyopathy nanNOT_YET_RECRUITING
Hemodynamic Assessment of underLying myocyTe Function in Right Heart Failure nanRECRUITING
LIPCAR, Cuproptosis, and Α-SMA in the Pathogenesis of AMI and Remodeling nanNOT_YET_RECRUITING
Effect of Aging & Obesity With Exercise Intervention nanCOMPLETED
Genetic Analysis of African-Americans With High Blood Pressure nanCOMPLETED
New Diagnostic Strategy in Hypertrophic Cardiomyopathy nanUNKNOWN
Pediatric Cardiomyopathy Mutation Analysis nanRECRUITING
Potential Synergistic Effect of Combined Blood Flow Restriction Training and Betaine Supplementation on Skeletal Muscle nanCOMPLETED
The Genetics of Cardiomyopathy and Heart Failure nanWITHDRAWN
A Single Center Prospective Study in an Estimated 570 Patients Who Underwent Genetic Screening at UZ Brussel in the Context of a Primary Cardiac Arrhythmia. Patients Showing a Variant Class 3,4 or 5 in SCN4A or CLCN1 Will Undergo a Clinical and Electrophysiological Review After IC. nanNOT_YET_RECRUITING
Chronic Muscle Disuse in the Elderly nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a MYH2 binder may also engage these)

ProteinNameSimilarity
Q076A7 1.000 Q076A7 →
Q9TV63 1.000 Q9TV63 →
Q9TV62 1.000 Q9TV62 →
Q9TV61 1.000 Q9TV61 →
Q076A6 1.000 Q076A6 →
G3UW82 1.000 G3UW82 →
Q8MJV1 1.000 Q8MJV1 →
P13535 1.000 P13535 →
Q9BE40 1.000 Q9BE40 →
Q076A4 1.000 Q076A4 →
P13542 1.000 P13542 →
Q8MJV0 1.000 Q8MJV0 →
P02565 1.000 P02565 →
Q9BE39 1.000 Q9BE39 →
P12882 1.000 P12882 →
P13533 1.000 P13533 →
P02564 1.000 P02564 →
P49824 1.000 P49824 →
Q9BE41 1.000 Q9BE41 →
Q076A5 1.000 Q076A5 →
Q28641 1.000 Q28641 →
Q5SX40 1.000 Q5SX40 →
P13538 1.000 P13538 →
P13540 1.000 P13540 →
Q02566 1.000 Q02566 →
P02563 1.000 P02563 →
Q9Y623 1.000 Q9Y623 →
P13539 1.000 P13539 →
P12883 1.000 P12883 →
Q9UKX3 1.000 Q9UKX3 →