Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.48 |
| ▸ | KIT | P10721 | 2/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.45 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31672469 | 1.00 | KDR (0.54) | KDRPDGFRBFGFR1EGFRPDPK1 | |
| SCHEMBL13755178 | 1.00 | KDR (0.54) | KDRPDGFRBFGFR1EGFRPDPK1 | |
| SCHEMBL31672464 | 0.85 | KDR (0.68) | KDRPDGFRBFGFR1EGFRPDPK1 | |
| SCHEMBL2116153 | 0.85 | KDR (0.68) | KDRPDGFRBFGFR1EGFRPDPK1 | |
| SCHEMBL13755173 | 0.85 | KDR (0.68) | KDRPDGFRBFGFR1EGFRPDPK1 | |
| SCHEMBL2116105 | 0.80 | PDGFRB (0.48) | KDRPDGFRBFGFR1EGFRKIT | |
| SCHEMBL31672427 | 0.80 | PDGFRB (0.48) | KDRPDGFRBFGFR1EGFRKIT | |
| SCHEMBL13755175 | 0.80 | PDGFRB (0.48) | KDRPDGFRBFGFR1EGFRKIT | |
| SCHEMBL3794502 | 0.79 | MEN1 (0.62) | KDRPDGFRBFGFR1PDPK1MEN1 | |
| SCHEMBL3794503 | 0.79 | MEN1 (0.62) | KDRPDGFRBFGFR1PDPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120094998-A1 | Oligomer-Protein Tyrosine Kinase Inhibitor Conjugates | NEKTAR THERAPEUTICS (US) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094998-A1 | Oligomer-Protein Tyrosine Kinase Inhibitor Conjugates | PTK2B, ERBB2, FRK | KDR 395/4885PDGFRB 555/4885FGFR1 462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.