Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 5/20 | 0.83 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | TYR | P14679 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL8524990 | 1.00 | ESR1 (0.83) | ESR1ESR2ALDH1A1L3MBTL1ADORA3 | |
| SCHEMBL31712141 | 0.92 | ESR1 (0.77) | ESR1ESR2ALDH1A1L3MBTL1ADORA3 | |
| SCHEMBL517000 | 0.92 | ESR1 (0.77) | ESR1ESR2ALDH1A1L3MBTL1ADORA3 | |
| SCHEMBL2131554 | 0.91 | ESR2 (1.00) | ESR1ESR2ALDH1A1L3MBTL1ADORA3 | |
| SCHEMBL10777847 | 0.91 | ESR2 (1.00) | ESR1ESR2ALDH1A1L3MBTL1ADORA3 | |
| SCHEMBL13379654 | 0.91 | ESR2 (1.00) | ESR1ESR2ALDH1A1L3MBTL1ADORA3 | |
| SCHEMBL13379655 | 0.91 | ESR2 (1.00) | ESR1ESR2ALDH1A1L3MBTL1ADORA3 | |
| SCHEMBL13379656 | 0.91 | ESR2 (1.00) | ESR1ESR2ALDH1A1L3MBTL1ADORA3 | |
| SCHEMBL13379657 | 0.91 | ESR2 (1.00) | ESR1ESR2ALDH1A1L3MBTL1ADORA3 | |
| SCHEMBL2132163 | 0.91 | ESR2 (1.00) | ESR1ESR2ALDH1A1L3MBTL1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11174347-B2 | Phthalimidine copolycarbonate optical articles, articles formed therefrom, and methods of manufacture | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2021-11-16 | — | — | US | disclosed |
| US-20200339745-A1 | PHTHALIMIDINE COPOLYCARBONATE OPTICAL ARTICLES, ARTICLES FORMED THEREFROM, AND METHODS OF MANUFACTURE | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2020-10-29 | — | — | US | disclosed |
| EP-3510078-B1 | PHTHALIMIDINE COPOLYCARBONATE OPTICAL ARTICLES, ARTICLES FORMED THEREFROM, AND METHODS OF MANUFACTURE | SABIC GLOBAL TECHNOLOGIES BV (NL) | 2020-06-03 | — | — | EP | disclosed |
| EP-3510078-A1 | PHTHALIMIDINE COPOLYCARBONATE OPTICAL ARTICLES, ARTICLES FORMED THEREFROM, AND METHODS OF MANUFACTURE | SABIC Global Technologies B.V. (NL) | 2019-07-17 | — | — | EP | disclosed |