Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A3 | P48764 | 7/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GFRA3 | O60609 | 2/20 | 0.43 |
| ▸ | GFRA2 | O00451 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | CCR3 | P51677 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.39 |
| ▸ | CASR | P41180 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20953608 | 0.96 | SLC9A3 (0.59) | SLC9A3KMT2AMAPTALDH1A1MEN1 | |
| SCHEMBL21142361 | 0.77 | SLC9A3 (1.00) | SLC9A3 | |
| SCHEMBL17273574 | 0.77 | SLC9A3 (1.00) | SLC9A3 | |
| SCHEMBL21142125 | 0.75 | SLC9A3 (0.66) | SLC9A3 | |
| SCHEMBL21350435 | 0.74 | SLC9A3 (0.92) | SLC9A3 | |
| SCHEMBL21142253 | 0.69 | SLC9A3 (0.73) | SLC9A3 | |
| SCHEMBL30099797 | 0.68 | ALDH1A1 (0.65) | KMT2AMAPTALDH1A1MEN1LMNA | |
| SCHEMBL1746652 | 0.67 | GFRA3 (0.63) | GFRA3GFRA2RET | |
| SCHEMBL8530467 | 0.67 | IDO1 (0.50) | GFRA3GFRA2RET | |
| SCHEMBL15616273 | 0.67 | SLC9A3 (0.83) | SLC9A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2887964-B1 | COMPOUNDS AND METHODS FOR INHIBITING NHE-MEDIATED ANTIPORT IN THE TREATMENT OF DISORDERS ASSOCIATED WITH FLUID RETENTION OR SALT OVERLOAD AND GASTROINTESTINAL TRACT DISORDERS | ARDELYX INC (US) | 2019-07-03 | — | — | EP | disclosed |