Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 14/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 13/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 12/20 | 1.00 |
| ▸ | APEX1 | P27695 | 9/20 | 1.00 |
| ▸ | RECQL | P46063 | 7/20 | 1.00 |
| ▸ | MAPT | P10636 | 5/20 | 1.00 |
| ▸ | CTDSP1 | Q9GZU7 | 4/20 | 1.00 |
| ▸ | NSD2 | O96028 | 3/20 | 1.00 |
| ▸ | PTPN7 | P35236 | 2/20 | 1.00 |
| ▸ | NR4A1 | P22736 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 1.00 |
| ▸ | HTT | P42858 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.61 |
| ▸ | MEN1 | O00255 | 5/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | PKM | P14618 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | PTP4A3 | O75365 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2114368 | 1.00 | POLB (1.00) | POLBL3MBTL1TDP1APEX1RECQL | |
| SCHEMBL3418447 | 1.00 | POLB (1.00) | POLBL3MBTL1TDP1APEX1RECQL | |
| SCHEMBL7824322 | 0.84 | L3MBTL1 (0.72) | POLBL3MBTL1TDP1APEX1RECQL | |
| SCHEMBL7824329 | 0.84 | L3MBTL1 (0.72) | POLBL3MBTL1TDP1APEX1RECQL | |
| SCHEMBL7826399 | 0.84 | L3MBTL1 (0.72) | POLBL3MBTL1TDP1APEX1RECQL | |
| SCHEMBL15330143 | 0.84 | POLB (0.72) | POLBL3MBTL1TDP1APEX1RECQL | |
| SCHEMBL7825568 | 0.83 | POLB (0.70) | POLBL3MBTL1TDP1APEX1RECQL | |
| SCHEMBL1389017 | 0.83 | POLB (0.70) | POLBL3MBTL1TDP1APEX1RECQL | |
| SCHEMBL1389018 | 0.83 | POLB (0.70) | POLBL3MBTL1TDP1APEX1RECQL | |
| Hydrochloric Acid SCHEMBL7827708 | 0.82 | POLB (0.69) | POLBL3MBTL1TDP1APEX1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090105240-A1 | Methods for treating leukemia and myelodysplastic syndrome, and methods for identifying agents for treating same | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | 2009-04-23 | — | — | US | claimed |
| US-20120095032-A1 | METHODS FOR TREATING LEUKEMIA AND MYELODYSPLASTIC SYNDROME, AND METHODS FOR IDENTIFYING AGENTS FOR TREATING SAME | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105240-A1 | Methods for treating leukemia and myelodysplastic syndrome, and methods for identifying agents for treating same | MCL1, AS3MT, MYADM | POLB 819/4885L3MBTL1 1464/4885TDP1 1293/4885 |
| US-20120095032-A1 | METHODS FOR TREATING LEUKEMIA AND MYELODYSPLASTIC SYNDROME, AND METHODS FOR IDENTIFYING AGENTS FOR TREATING SAME | MCL1, AS3MT, MYADM | POLB 819/4885L3MBTL1 1464/4885TDP1 1293/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.