Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.44 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.41 |
| ▸ | IDH1 | O75874 | 4/20 | 0.41 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.40 |
| ▸ | IDH2 | P48735 | 2/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.37 |
| ▸ | WHR1 | P49842 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | BCL6 | P41182 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31127257 | 1.00 | KMT2A (0.47) | KMT2ATRPM8EHMT2IDH1EHMT1 | |
| SCHEMBL3145566 | 0.87 | KMT2A (0.51) | KMT2ATRPM8EHMT2AXLKDM4E | |
| SCHEMBL27196854 | 0.85 | KMT2A (0.60) | KMT2ATRPM8EHMT2EHMT1AXL | |
| SCHEMBL12526913 | 0.81 | NSD2 (0.46) | KMT2ATRPM8EHMT2AXLALDH1A1 | |
| Hydrochloric Acid SCHEMBL1748440 | 0.80 | NSD2 (0.46) | KMT2ATRPM8EHMT2AXLALDH1A1 | |
| SCHEMBL19687464 | 0.79 | KMT2A (0.47) | KMT2AIDH1IDH2AXLMAPK8 | |
| SCHEMBL25902571 | 0.78 | TRPM8 (0.41) | KMT2ATRPM8EHMT2AXLKDM4E | |
| SCHEMBL26627801 | 0.76 | LRRK2 (0.45) | KMT2ATRPM8EHMT2LRRK2 | |
| SCHEMBL30462044 | 0.76 | LRRK2 (0.45) | KMT2ATRPM8EHMT2LRRK2 | |
| SCHEMBL21143941 | 0.76 | USP2 (0.46) | KMT2AEHMT2IDH1EHMT1IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10774064-B2 | Potassium channel modulators | CADENT THERAPEUTICS, INC. (US) | 2020-09-15 | — | — | US | disclosed |
| US-10774064-B2 | Potassium channel modulators | CADENT THERAPEUTICS, INC. (US) | 2020-09-15 | — | — | US | disclosed |
| US-20190218200-A1 | POTASSIUM CHANNEL MODULATORS | NOVARTIS AG (CH) | 2019-07-18 | — | — | US | disclosed |
| US-20190218200-A1 | POTASSIUM CHANNEL MODULATORS | NOVARTIS AG (CH) | 2019-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10774064-B2 | Potassium channel modulators | KCNJ11, KCNJ2, KCNJ1 | KMT2A 1471/4885TRPM8 82/4885EHMT2 3277/4885 |
| US-20190218200-A1 | POTASSIUM CHANNEL MODULATORS | KCNJ11, KCNJ2, KCNJ1 | KMT2A 1471/4885TRPM8 82/4885EHMT2 3277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.