Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 10/20 | 0.39 |
| ▸ | IDH2 | P48735 | 1/20 | 0.39 |
| ▸ | FABP4 | P15090 | 8/20 | 0.37 |
| ▸ | FABP5 | Q01469 | 8/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21165855 | 0.91 | IDH1 (0.41) | IDH1IDH2FABP4FABP5 | |
| SCHEMBL21143848 | 0.85 | IDH1 (0.43) | IDH1IDH2FABP4FABP5 | |
| SCHEMBL21143959 | 0.84 | IDH1 (0.40) | IDH1IDH2FABP4FABP5ABCB1 | |
| SCHEMBL19687423 | 0.84 | TGFBR1 (0.35) | IDH1IDH2FABP4FABP5 | |
| SCHEMBL31127061 | 0.82 | IDH1 (0.41) | IDH1IDH2FABP4FABP5 | |
| SCHEMBL19686740 | 0.82 | IDH1 (0.41) | IDH1IDH2FABP4FABP5 | |
| SCHEMBL21144218 | 0.82 | IDH1 (0.38) | IDH1IDH2FABP4FABP5 | |
| SCHEMBL19687049 | 0.82 | IDH1 (0.43) | IDH1IDH2FABP4FABP5 | |
| SCHEMBL19687089 | 0.81 | IDH1 (0.39) | IDH1IDH2FABP4FABP5 | |
| SCHEMBL21143866 | 0.81 | IDH1 (0.39) | IDH1IDH2FABP4FABP5GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190218200-A1 | POTASSIUM CHANNEL MODULATORS | NOVARTIS AG (CH) | 2019-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190218200-A1 | POTASSIUM CHANNEL MODULATORS | KCNJ11, KCNJ2, KCNJ1 | IDH1 3017/4885IDH2 2447/4885FABP4 2531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.