Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.32 |
| ▸ | ABL1 | P00519 | 4/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL212116 | 0.95 | CTSK (0.36) | CTSKNOTUMALDH1A1CSNK1DABL1 | |
| SCHEMBL211405 | 0.95 | CTSK (0.35) | CTSKNOTUMPPARGPPARAALDH1A1 | |
| SCHEMBL211861 | 0.93 | CTSK (0.34) | CTSKNOTUMPPARGPPARAABL1 | |
| SCHEMBL212341 | 0.93 | CTSK (0.37) | CTSKNOTUMALDH1A1CSNK1DABL1 | |
| SCHEMBL212782 | 0.92 | CTSK (0.34) | CTSKNOTUMPPARGPPARAALDH1A1 | |
| SCHEMBL211672 | 0.91 | CTSK (0.36) | CTSKNOTUMALDH1A1CSNK1DABL1 | |
| SCHEMBL4353508 | 0.91 | CTSK (0.37) | CTSKNOTUMALDH1A1CSNK1DABL1 | |
| SCHEMBL210077 | 0.90 | NOTUM (0.36) | CTSKNOTUMALDH1A1CSNK1DABL1 | |
| SCHEMBL210546 | 0.90 | CTSK (0.34) | CTSKNOTUMPPARGPPARAALDH1A1 | |
| SCHEMBL212590 | 0.90 | CTSK (0.36) | CTSKNOTUMALDH1A1CSNK1DABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | claimed |
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |