Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.51 |
| ▸ | DRD3 | P35462 | 8/20 | 0.51 |
| ▸ | DRD4 | P21917 | 8/20 | 0.49 |
| ▸ | HTR1A | P08908 | 7/20 | 0.49 |
| ▸ | DRD1 | P21728 | 7/20 | 0.49 |
| ▸ | DRD5 | P21918 | 7/20 | 0.49 |
| ▸ | LIPE | Q05469 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30010653 | 1.00 | DRD2 (0.51) | DRD2DRD3DRD4HTR1ADRD1 | |
| SCHEMBL13974997 | 1.00 | DRD2 (0.51) | DRD2DRD3DRD4HTR1ADRD1 | |
| SCHEMBL21936084 | 0.86 | NTRK1 (0.43) | DRD2DRD3DRD4HTR1ADRD1 | |
| SCHEMBL13858452 | 0.86 | NTRK1 (0.43) | DRD2DRD3DRD4HTR1ADRD1 | |
| SCHEMBL22415911 | 0.84 | DRD2 (0.51) | DRD2DRD3DRD4HTR1ADRD1 | |
| SCHEMBL22415904 | 0.83 | DRD2 (0.65) | DRD2DRD3DRD4HTR1ADRD1 | |
| SCHEMBL13975017 | 0.83 | DRD2 (0.65) | DRD2DRD3DRD4HTR1ADRD1 | |
| SCHEMBL30010274 | 0.83 | DRD2 (0.50) | DRD2DRD3HTR1ADRD1DRD5 | |
| SCHEMBL22415828 | 0.83 | DRD2 (0.50) | DRD2DRD3HTR1ADRD1DRD5 | |
| SCHEMBL21148130 | 0.83 | SLC18A3 (0.57) | DRD2DRD3DRD4DRD1DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3409670-B1 | N-PYRROLIDINYL, N'-PYRAZOLYL- UREA COMPOUNDS AS TRKA KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2020-09-09 | — | — | EP | disclosed |
| EP-3564236-A1 | PROCESS FOR PREPARING 4-SUBSTITUTED-1-(2-METHOXYETHYL)PYRROLIDIN-3-AMINE DERIVATIVES | Array Biopharma, Inc. (US) | 2019-11-06 | — | — | EP | disclosed |
| CN-106459013-B | Compounds as TRKA kinase inhibitors and uses thereof | 阵列生物制药公司 | 2019-10-25 | — | — | CN | disclosed |
| EP-3154959-B1 | 1-((3S,4R)-4-(3-FLUOROPHENYL)-1-(2-METHOXYETHYL)PYRROLIDIN-3-YL)-3-(4-METHYL-3-(2-METHYLPYRIMIDIN-5-YL)-1-PHENYL-1H-PYRAZOL-5-YL)UREA AS A TRKA KINASE INHIBITOR | ARRAY BIOPHARMA INC (US) | 2019-07-10 | — | — | EP | disclosed |
| CN-109970614-A | Compound and application thereof as TRKA kinase inhibitor | 阵列生物制药公司 | 2019-07-05 | — | — | CN | disclosed |
| CN-106459013-A | 1- ((3S, 4R) -4- (3-fluorophenyl) -1- (2-methoxyethyl) pyrrolidin-3-yl) -3- (4-methyl-3- (2-methylpyrimidin-5-yl) -1-phenyl-1H-pyrazol-5-yl) urea as TRKA kinase inhibitors | 阵列生物制药公司 | 2017-02-22 | — | — | CN | disclosed |