Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.31 |
| ▸ | CTSA | P10619 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2112279 | 0.78 | CTSA (0.39) | ABL1DGAT1CTSA | |
| SCHEMBL2114140 | 0.78 | DGAT1 (0.42) | DGAT1 | |
| SCHEMBL2600613 | 0.78 | ABL1 (0.53) | ABL1MAP4K1CTSA | |
| SCHEMBL2112187 | 0.72 | ABL1 (0.53) | ABL1MAP4K1CTSA | |
| SCHEMBL2600635 | 0.71 | ABL1 (0.53) | ABL1MAP4K1CTSA | |
| SCHEMBL2600623 | 0.71 | ABL1 (0.51) | ABL1MAP4K1CTSA | |
| SCHEMBL2113505 | 0.70 | ABL1 (0.52) | ABL1MAP4K1CTSA | |
| SCHEMBL2113615 | 0.70 | ABL1 (0.52) | ABL1MAP4K1CTSA | |
| SCHEMBL2600614 | 0.70 | ABL1 (0.52) | ABL1MAP4K1CTSA | |
| SCHEMBL2600675 | 0.70 | ABL1 (0.51) | ABL1MAP4K1CTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158647-B2 | Substituted pyrrolopyridines and pyrazolopyridines as kinase modulators | SGX PHARMACEUTICALS, INC. (US) | 2012-04-17 | — | — | US | disclosed |