Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 10/20 | 0.43 |
| ▸ | KDR | P35968 | 10/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.43 |
| ▸ | EGFR | P00533 | 5/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 7/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2114117 | 0.83 | KDR (0.46) | PDGFRBKDRFGFR1EGFRCHEK1 | |
| SCHEMBL2116155 | 0.82 | MEN1 (0.47) | PDGFRBKDRFGFR1EGFRSRC | |
| SCHEMBL2114542 | 0.77 | PDGFRB (0.45) | PDGFRBKDRFGFR1EGFRCHEK1 | |
| SCHEMBL2114116 | 0.76 | LRRK2 (0.42) | PDGFRBKDRFGFR1EGFRSRC | |
| SCHEMBL2114389 | 0.75 | FLT3 (0.41) | PDGFRBKDRFGFR1EGFRCHEK1 | |
| SCHEMBL2116248 | 0.74 | KDR (0.40) | PDGFRBKDRFGFR1EGFRCHEK1 | |
| SCHEMBL2113982 | 0.73 | KDR (0.47) | PDGFRBKDRFGFR1EGFRCHEK1 | |
| SCHEMBL2118752 | 0.73 | KDR (0.46) | PDGFRBKDRFGFR1EGFRCHEK1 | |
| SCHEMBL399058 | 0.69 | FLT3 (0.48) | PDGFRBKDRAURKBNTRK1MET | |
| SCHEMBL2115597 | 0.68 | MEN1 (0.41) | PDGFRBKDRFGFR1EGFRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120094998-A1 | Oligomer-Protein Tyrosine Kinase Inhibitor Conjugates | NEKTAR THERAPEUTICS (US) | 2012-04-19 | — | — | US | disclosed |
| US-7125905-B2 | Pyrrole substituted 2-indolinone protein kinase inhibitors | AGOURON PHARMACEUTICALS, INC. (US) | 2006-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094998-A1 | Oligomer-Protein Tyrosine Kinase Inhibitor Conjugates | PTK2B, ERBB2, FRK | PDGFRB 555/4885KDR 395/4885FGFR1 462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.