SCHEMBL21152

SCHEMBL21152

Cc1[nH]nc(C(F)F)c1C(=O)O

nearest known ligand 0.44

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 5/20 0.44
PDE4D Q08499 1/20 0.38
DAO P14920 1/20 0.37
NOTUM Q6P988 1/20 0.34
JAK1 P23458 1/20 0.33
KMT2A Q03164 3/20 0.33
KDM4E B2RXH2 1/20 0.33
POLB P06746 1/20 0.33
MAPT P10636 1/20 0.33
HSP90AA1 P07900 1/20 0.32
HSP90AB1 P08238 1/20 0.32
MEN1 O00255 2/20 0.32
LMNA P02545 1/20 0.32
ALDH1A1 P00352 1/20 0.32
HCAR3 P49019 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5317321 0.83 PDE4D (0.37) HCAR2PDE4DJAK1KMT2AKDM4E
SCHEMBL28100203 0.83 CSNK2A2 (0.39) HCAR2PDE4DJAK1KMT2AKDM4E
SCHEMBL22637832 0.82 HCAR2 (0.41) HCAR2PDE4DDAONOTUMKMT2A
SCHEMBL29217463 0.78 HCAR2 (0.33) HCAR2
SCHEMBL17709538 0.78
SCHEMBL19187 0.78 PDE4D (0.65) PDE4DKMT2AKDM4EPOLBMAPT
SCHEMBL29129805 0.77 GLRA3 (0.31) HCAR2
SCHEMBL15166428 0.74 L3MBTL1 (0.30)
SCHEMBL19188 0.74 HCAR2 (0.45) HCAR2HCAR3
SCHEMBL6109414 0.73 HCAR2 (0.36) HCAR2DAOHCAR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117070968-A Synthesis method of difluoromethyl alkyl pyrazole carboxylic acid 山东京博农化科技股份有限公司 2023-11-17 CN disclosed
CN-114195715-A Process for preparing 1-methyl-3-difluoromethyl-4-pyrazolic acid and 1-methyl-3-trifluoromethyl-4-pyrazolic acid 福建永晶科技股份有限公司 2022-03-18 CN disclosed
CN-105218448-B A kind of synthetic method of the pyrazole carboxylic acid of 1 methyl, 3 difluoromethyl 4 江苏恒润制药有限公司 2017-11-07 CN disclosed
WO-2015155713-A1 PROCESS FOR THE REGIOSELECTIVE SYNTHESIS OF 1,3, 4 -SUBSTITUTED PYRAZOLES ISAGRO S.P.A. (IT) 2015-10-15 WO disclosed
EP-2595962-A1 PROCESS FOR THE PREPARATION OF ESTERS OF 1-SUBSTITUTED-3-FLUOROALKYL-PYRAZOLE-4-CARBOXYLIC ACIDS SOLVAY SA (BE) 2013-05-29 EP disclosed
WO-2012025469-A1 IMPROVED PROCESS FOR THE PREPARATION OF ESTERS OF 1-H-PYRAZOLE-4-CARBOXYLIC ACIDS SOLVAY SA (BE) 2012-03-01 WO disclosed
WO-2012010692-A1 PROCESS FOR THE PREPARATION OF ESTERS OF 1-SUBSTITUTED-3-FLUOROALKYL-PYRAZOLE-4-CARBOXYLIC ACIDS SOLVAY SA (BE) 2012-01-26 WO disclosed
EP-1765764-A1 PROCESS FOR THE PREPARATION OF 4,4-DIFLUORO-3-OXOBUTANOIC ACID ESTERS Syngeta Participations AG (CH) 2007-03-28 EP disclosed
WO-2006005612-A1 PROCESS FOR THE PREPARATION OF 4,4-DIFLUORO-3-OXOBUTANOIC ACID ESTERS SYNGENTA PARTICIPATIONS AG (CH) 2006-01-19 WO disclosed