Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 3/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.44 |
| ▸ | PIM1 | P11309 | 2/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.44 |
| ▸ | LTK | P29376 | 2/20 | 0.36 |
| ▸ | MST1R | Q04912 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21152989 | 0.78 | CLK4 (0.35) | CDK5DYRK1ACLK4PIM1CSNK1A1 | |
| SCHEMBL21153005 | 0.71 | KDR (0.43) | CDK5DYRK1ACLK4PIM1CSNK1A1 | |
| SCHEMBL31385355 | 0.69 | CDK5 (0.47) | CDK5DYRK1ACLK4PIM1CSNK1A1 | |
| SCHEMBL31385354 | 0.69 | CDK5 (0.47) | CDK5DYRK1ACLK4PIM1CSNK1A1 | |
| SCHEMBL21152484 | 0.68 | MAP3K5 (0.38) | — | |
| SCHEMBL21152480 | 0.65 | PDE3B (0.33) | — | |
| SCHEMBL1333810 | 0.61 | CLK4 (1.00) | CDK5DYRK1ACLK4PIM1CSNK1A1 | |
| SCHEMBL24466480 | 0.60 | CDK5 (0.55) | CDK5DYRK1ACLK4PIM1CSNK1A1 | |
| SCHEMBL21152485 | 0.59 | MAP3K9 (0.48) | CHEK1PRKD3NTRK1PRKACAPRKCQ | |
| SCHEMBL24147834 | 0.59 | CLK4 (0.53) | CDK5DYRK1ACLK4PIM1CSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3735404-B1 | ASK1 INHIBITOR COMPOUNDS AND USES THEREOF | SEAL ROCK THERAPEUTICS INC (US) | 2023-11-29 | — | — | EP | disclosed |
| WO-2020046975-A1 | METHODS OF TREATING NEURODEGENERATIVE DISEASES | Seal Rock Therapeutics, Inc. (US) | 2020-03-05 | — | — | WO | disclosed |
| WO-2019136025-A1 | ASK1 INHIBITOR COMPOUNDS AND USES THEREOF | Seal Rock Therapeutics, Inc. (US) | 2019-07-11 | — | — | WO | disclosed |