Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | KDM5C | P41229 | 1/20 | 0.34 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.34 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.32 |
| ▸ | AOC2 | O75106 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17304513 | 0.91 | CTSD (0.42) | CTSDKDM4EKDM5CPHF8KDM2A | |
| SCHEMBL2827132 | 0.80 | — | — | |
| SCHEMBL17304512 | 0.79 | CTSD (0.39) | CTSDKDM4EKDM5CPHF8KDM2A | |
| SCHEMBL12335996 | 0.79 | CTSD (0.46) | CTSDKDM4EKDM5CPHF8KDM2A | |
| SCHEMBL20224633 | 0.79 | MCL1 (0.34) | LMNA | |
| SCHEMBL26893756 | 0.77 | CTSD (0.40) | CTSDKDM4EKDM5CPHF8KDM2A | |
| SCHEMBL24419413 | 0.74 | KMT2A (0.38) | ALDH1A1LMNA | |
| SCHEMBL12308797 | 0.74 | CTSD (0.37) | CTSDKDM4EKDM5CPHF8KDM2A | |
| SCHEMBL23265399 | 0.73 | — | — | |
| SCHEMBL7083891 | 0.73 | KDM4E (0.36) | KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3735404-B1 | ASK1 INHIBITOR COMPOUNDS AND USES THEREOF | SEAL ROCK THERAPEUTICS INC (US) | 2023-11-29 | — | — | EP | disclosed |
| WO-2019136025-A1 | ASK1 INHIBITOR COMPOUNDS AND USES THEREOF | Seal Rock Therapeutics, Inc. (US) | 2019-07-11 | — | — | WO | disclosed |