Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 20/20 | 0.76 |
| ▸ | ADORA1 | P30542 | 19/20 | 0.76 |
| ▸ | ADORA2A | P29274 | 18/20 | 0.76 |
| ▸ | ADORA3 | P0DMS8 | 10/20 | 0.62 |
| ▸ | PLK4 | O00444 | 1/20 | 0.58 |
| ▸ | CDK2 | P24941 | 1/20 | 0.58 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.58 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.58 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.58 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30291859 | 0.91 | ADORA2B (0.62) | ADORA2BADORA1ADORA2AADORA3PLK4 | |
| SCHEMBL21121530 | 0.91 | ADORA2B (0.76) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL21121160 | 0.91 | ADORA2B (0.62) | ADORA2BADORA1ADORA2AADORA3PLK4 | |
| SCHEMBL23067585 | 0.91 | ADORA2B (0.74) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL23067642 | 0.90 | ADORA2B (0.77) | ADORA2BADORA1ADORA2AADORA3PLK4 | |
| SCHEMBL21153172 | 0.89 | ADORA2B (0.60) | ADORA2BADORA1ADORA2AADORA3PLK4 | |
| SCHEMBL24591548 | 0.89 | ADORA2B (0.60) | ADORA2BADORA1ADORA2AADORA3PLK4 | |
| SCHEMBL21153173 | 0.89 | ADORA2B (0.60) | ADORA2BADORA1ADORA2AADORA3PLK4 | |
| SCHEMBL21121161 | 0.89 | ADORA2B (0.77) | ADORA2BADORA1ADORA2AADORA3PLK4 | |
| SCHEMBL30291862 | 0.89 | ADORA2B (0.60) | ADORA2BADORA1ADORA2AADORA3PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019135259-A1 | TRICYCLIC COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF | IMPETIS BIOSCIENCES LTD. (IN) | 2019-07-11 | — | — | WO | disclosed |