Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | APAF1 | O14727 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CASR | P41180 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14469578 | 0.83 | SMN1; SMN2 (0.82) | SMN1; SMN2APAF1MEN1KMT2ACASR | |
| SCHEMBL29560 | 0.80 | SMN1; SMN2 (0.76) | SMN1; SMN2APAF1MEN1KMT2ACASR | |
| SCHEMBL774613 | 0.80 | SMN1; SMN2 (0.76) | SMN1; SMN2APAF1MEN1KMT2ACASR | |
| SCHEMBL79765 | 0.80 | SMN1; SMN2 (0.76) | SMN1; SMN2APAF1MEN1KMT2ACASR | |
| SCHEMBL7176489 | 0.79 | SMN1; SMN2 (0.70) | SMN1; SMN2APAF1MEN1KMT2ACASR | |
| SCHEMBL9089267 | 0.79 | SMN1; SMN2 (0.70) | SMN1; SMN2APAF1MEN1KMT2ACASR | |
| SCHEMBL13077596 | 0.79 | SMN1; SMN2 (0.70) | SMN1; SMN2APAF1MEN1KMT2ACASR | |
| SCHEMBL19570479 | 0.79 | SMN1; SMN2 (0.70) | SMN1; SMN2MEN1KMT2ACASRCYP2D6 | |
| SCHEMBL4424042 | 0.79 | SMN1; SMN2 (0.70) | SMN1; SMN2APAF1MEN1KMT2ACASR | |
| Hydrochloric Acid SCHEMBL9635019 | 0.78 | SMN1; SMN2 (0.79) | SMN1; SMN2MEN1KMT2ACASRCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190210959-A1 | Small molecule drugs and related methods for treatment of diseases related to abeta42 oligomer formation | ACELOT, INC. | 2019-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190210959-A1 | Small molecule drugs and related methods for treatment of diseases related to abeta42 oligomer formation | APP, PSEN2, PSEN1 | SMN1; SMN2 433/4885APAF1 2641/4885HDAC1 3591/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.