Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | ACP1 | P24666 | 6/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21121668 | 0.91 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2HTTNPSR1MEN1 | |
| SCHEMBL21121783 | 0.90 | SMN1; SMN2 (0.54) | ALDH1A1SMN1; SMN2HTTNPSR1MEN1 | |
| SCHEMBL21121877 | 0.90 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2HTTNPSR1MEN1 | |
| SCHEMBL21121898 | 0.90 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2HTTNPSR1MEN1 | |
| SCHEMBL21121767 | 0.90 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2HTTNPSR1MEN1 | |
| SCHEMBL21121750 | 0.89 | SMN1; SMN2 (0.56) | ALDH1A1SMN1; SMN2HTTNPSR1MEN1 | |
| SCHEMBL21121616 | 0.88 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2NPSR1MEN1KMT2A | |
| SCHEMBL21121843 | 0.88 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2HTTNPSR1MEN1 | |
| SCHEMBL21121785 | 0.88 | SMN1; SMN2 (0.52) | ALDH1A1SMN1; SMN2HTTNPSR1MEN1 | |
| SCHEMBL21121615 | 0.88 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2HTTNPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200338084-A1 | INHIBITORS OF LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE (LMPTP) AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute | 2020-10-29 | — | — | US | claimed |
| US-20200338084-A1 | INHIBITORS OF LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE (LMPTP) AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute | 2020-10-29 | — | — | US | disclosed |
| US-20200338084-A1 | INHIBITORS OF LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE (LMPTP) AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute | 2020-10-29 | — | — | US | disclosed |
| WO-2019136093-A1 | INHIBITORS OF LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE (LMPTP) AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute (US) | 2019-07-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200338084-A1 | INHIBITORS OF LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE (LMPTP) AND USES THEREOF | ACP1, PTPRCAP, PTPRO | ALDH1A1 3948/4885SMN1; SMN2 4712/4885HTT 3208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.