Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLD1 | Q13393 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22425261 | 0.76 | USP30 (0.36) | USP30SMN1; SMN2KDM4E | |
| SCHEMBL22425353 | 0.76 | CCR1 (0.39) | GRIN2BUSP30SMN1; SMN2GRIN2DGRIN3B | |
| SCHEMBL24195083 | 0.75 | GRIN2D (0.37) | GRIN2BUSP30SMN1; SMN2GRIN2DGRIN3B | |
| SCHEMBL24195082 | 0.75 | GRIN2D (0.37) | GRIN2BUSP30SMN1; SMN2GRIN2DGRIN3B | |
| SCHEMBL21154527 | 0.74 | CNR2 (0.35) | USP30SMN1; SMN2 | |
| SCHEMBL21154522 | 0.74 | CNR2 (0.35) | USP30SMN1; SMN2 | |
| SCHEMBL21588488 | 0.74 | GRIN2D (0.36) | GRIN2BUSP30GRIN2DGRIN3BGRIN1 | |
| SCHEMBL21154010 | 0.74 | CNR2 (0.35) | USP30SMN1; SMN2 | |
| SCHEMBL22000882 | 0.74 | CNR2 (0.35) | USP30SMN1; SMN2 | |
| SCHEMBL21999969 | 0.74 | CNR2 (0.35) | USP30SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019134978-A1 | 1, 3, 4, 5-TETRAHYDRO-2H-PYRIDO[4,3-B]INDOLE DERIVATIVES FOR THE TREATMENT, ALLEVIATION OR PREVENTION OF DISORDERS ASSOCIATED WITH TAU AGGREGATES LIKE ALZHEIMER'S DISEASE | AC IMMUNE SA (CH) | 2019-07-11 | — | — | WO | disclosed |