SCHEMBL21154890

SCHEMBL21154890

CCCCNC(=O)c1nn(Cc2ccc(Cl)cc2Cl)c2ccccc12

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.67
CYP3A4 P08684 2/20 0.67
CYP2C9 P11712 2/20 0.67
CYP2D6 P10635 1/20 0.67
TSHR P16473 1/20 0.67
PMP22 Q01453 1/20 0.67
HIF1A Q16665 1/20 0.67
NPSR1 Q6W5P4 1/20 0.67
PTGER4 P35408 4/20 0.51
CNR2 P34972 10/20 0.50
CNR1 P21554 7/20 0.50
POLB P06746 1/20 0.45
LMNA P02545 2/20 0.44
CYP2C19 P33261 1/20 0.44
TP53 P04637 2/20 0.44
JAK2 O60674 1/20 0.44
ALDH1A1 P00352 1/20 0.44
HTT P42858 1/20 0.44
RAB9A P51151 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21154852 0.97 CYP1A2 (0.66) CYP1A2CYP3A4CYP2C9CYP2D6TSHR
SCHEMBL21155282 0.97 CYP1A2 (0.66) CYP1A2CYP3A4CYP2C9CYP2D6TSHR
SCHEMBL21154835 0.97 CYP1A2 (0.66) CYP1A2CYP3A4CYP2C9CYP2D6TSHR
SCHEMBL24468087 0.90 TSHR (0.67) CYP1A2CYP3A4CYP2C9CYP2D6TSHR
SCHEMBL14595147 0.90 CYP1A2 (0.72) CYP1A2CYP3A4CYP2C9CYP2D6TSHR
SCHEMBL24468058 0.89 CYP1A2 (0.66) CYP1A2CYP3A4CYP2C9CYP2D6TSHR
SCHEMBL14584137 0.89 TSHR (0.71) CYP1A2CYP3A4CYP2C9CYP2D6TSHR
SCHEMBL21155363 0.88 CYP1A2 (0.61) CYP1A2CYP3A4CYP2C9CYP2D6TSHR
SCHEMBL24486720 0.85 CYP1A2 (0.75) CYP1A2CYP3A4CYP2C9CYP2D6TSHR
SCHEMBL996941 0.84 CYP1A2 (0.77) CYP1A2CYP3A4CYP2C9CYP2D6TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019136154-A1 MITO-LONIDAMINE, COMPOSITIONS AND METHODS OF USE THE MEDICAL COLLEGE OF WISCONSIN, INC. (US) 2019-07-11 WO disclosed