Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 9/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.49 |
| ▸ | EGFR | P00533 | 7/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 9/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.37 |
| ▸ | TUBB | P07437 | 1/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.37 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.37 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.37 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.37 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.37 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.37 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2115777 | 0.86 | PDGFRB (0.47) | KDRPDGFRBFGFR1EGFRSRC | |
| SCHEMBL2118752 | 0.84 | KDR (0.46) | KDRPDGFRBFGFR1EGFRSRC | |
| SCHEMBL2116213 | 0.82 | FGFR1 (0.51) | KDRPDGFRBFGFR1EGFRSRC | |
| SCHEMBL2113955 | 0.81 | MEN1 (0.43) | KDRPDGFRBFGFR1EGFRKIT | |
| SCHEMBL3795615 | 0.77 | KDR (0.67) | KDRPDGFRBFGFR1EGFRSRC | |
| SCHEMBL3795423 | 0.77 | KDR (0.67) | KDRPDGFRBFGFR1EGFRSRC | |
| SCHEMBL2114117 | 0.76 | KDR (0.46) | KDRPDGFRBFGFR1EGFRSRC | |
| SCHEMBL394231 | 0.75 | FLT3 (0.50) | KDRPDGFRBKITFLT4FLT3 | |
| SCHEMBL3718409 | 0.74 | KDR (0.73) | KDRPDGFRBFGFR1EGFRSRC | |
| SCHEMBL4467534 | 0.74 | KDR (0.73) | KDRPDGFRBFGFR1EGFRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120094998-A1 | Oligomer-Protein Tyrosine Kinase Inhibitor Conjugates | NEKTAR THERAPEUTICS (US) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094998-A1 | Oligomer-Protein Tyrosine Kinase Inhibitor Conjugates | PTK2B, ERBB2, FRK | KDR 395/4885PDGFRB 555/4885FGFR1 462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.