Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1186099 | 0.77 | KDM4E (0.68) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL31590423 | 0.76 | KDM4E (0.66) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1417913 | 0.76 | KDM4E (0.81) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL21154842 | 0.75 | GDA (0.37) | KDM4EALDH1A1SMN1; SMN2GAAHSD17B10 | |
| SCHEMBL4896898 | 0.75 | ALDH1A1 (0.46) | KDM4EALDH1A1KMT2ALMNAGAA | |
| SCHEMBL21227043 | 0.74 | KDM4E (0.64) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2491314 | 0.74 | KDM4E (0.64) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL3023145 | 0.74 | KDM4E (0.64) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL13815988 | 0.74 | KDM4E (0.64) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL950248 | 0.74 | KDM4E (0.64) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019134680-A1 | INHIBITOR OF APOPTOSIS SIGNAL-REGULATING KINASE-1 AND APPLICATION THEREOF | 广州市恒诺康医药科技有限公司 | 2019-07-11 | — | — | WO | disclosed |