Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 3/20 | 0.75 |
| ▸ | JAK2 | O60674 | 1/20 | 0.62 |
| ▸ | BRD4 | O60885 | 1/20 | 0.62 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.61 |
| ▸ | KDR | P35968 | 3/20 | 0.61 |
| ▸ | EGFR | P00533 | 3/20 | 0.59 |
| ▸ | PTK2 | Q05397 | 9/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.51 |
| ▸ | FES | P07332 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | ROS1 | P08922 | 1/20 | 0.51 |
| ▸ | CDK4 | P11802 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | JAK1 | P23458 | 1/20 | 0.51 |
| ▸ | TYK2 | P29597 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | EPHB1 | P54762 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.51 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19119650 | 0.90 | FGFR2 (0.81) | FGFR2JAK2BRD4FGFR1KDR | |
| SCHEMBL29848096 | 0.89 | FGFR2 (0.71) | FGFR2JAK2BRD4FGFR1KDR | |
| SCHEMBL16515483 | 0.89 | FGFR2 (0.71) | FGFR2JAK2BRD4FGFR1KDR | |
| SCHEMBL20807734 | 0.88 | FGFR1 (0.77) | FGFR2JAK2BRD4FGFR1KDR | |
| SCHEMBL16513666 | 0.86 | FGFR2 (1.00) | FGFR2JAK2BRD4FGFR1KDR | |
| SCHEMBL20807685 | 0.85 | EGFR (0.79) | FGFR2JAK2BRD4FGFR1KDR | |
| Maleic Acid SCHEMBL16514711 | 0.83 | FGFR2 (0.93) | FGFR2JAK2BRD4FGFR1KDR | |
| Fumaric Acid SCHEMBL16823056 | 0.83 | FGFR2 (0.93) | FGFR2JAK2BRD4FGFR1KDR | |
| SCHEMBL22464992 | 0.81 | FGFR2 (0.87) | FGFR2JAK2BRD4FGFR1KDR | |
| SCHEMBL16515032 | 0.81 | FGFR2 (0.87) | FGFR2JAK2BRD4FGFR1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3508204-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Neupharma, Inc. (US) | 2019-07-10 | — | — | EP | disclosed |