Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.80 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.64 |
| ▸ | BTK | Q06187 | 11/20 | 0.59 |
| ▸ | JAK3 | P52333 | 1/20 | 0.59 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 1/20 | 0.58 |
| ▸ | FLT3 | P36888 | 3/20 | 0.57 |
| ▸ | BLK | P51451 | 3/20 | 0.57 |
| ▸ | ITK | Q08881 | 4/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29847707 | 0.90 | EGFR (0.85) | EGFRFGFR2BTKJAK3ITK | |
| SCHEMBL16514391 | 0.90 | EGFR (0.85) | EGFRFGFR2BTKJAK3ITK | |
| SCHEMBL16514281 | 0.89 | EGFR (1.00) | EGFRFGFR2BTKJAK3FGFR1 | |
| SCHEMBL29847612 | 0.89 | EGFR (1.00) | EGFRFGFR2BTKJAK3FGFR1 | |
| SCHEMBL20807715 | 0.89 | EGFR (0.77) | EGFRFGFR2BTKJAK3FGFR1 | |
| SCHEMBL20807754 | 0.88 | EGFR (0.75) | EGFRFGFR2BTKJAK3FGFR1 | |
| SCHEMBL16514613 | 0.87 | EGFR (0.83) | EGFRFGFR2BTKJAK3FGFR1 | |
| SCHEMBL29848073 | 0.87 | EGFR (0.83) | EGFRFGFR2BTKJAK3FGFR1 | |
| SCHEMBL21155307 | 0.86 | EGFR (0.76) | EGFRFGFR2BTKJAK3FGFR1 | |
| SCHEMBL16513855 | 0.85 | EGFR (0.80) | EGFRFGFR2BTKJAK3FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3508204-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Neupharma, Inc. (US) | 2019-07-10 | — | — | EP | disclosed |