Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAT2 | Q10469 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 5/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.40 |
| ▸ | KDR | P35968 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.37 |
| ▸ | AURKA | O14965 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 4/20 | 0.36 |
| ▸ | LCK | P06239 | 3/20 | 0.36 |
| ▸ | YES1 | P07947 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2116512 | 0.89 | PRKDC (0.39) | MGAT2METFGFR1KDRMEN1 | |
| SCHEMBL2116565 | 0.85 | MGAT2 (0.44) | MGAT2METFGFR1KDRMEN1 | |
| SCHEMBL2114228 | 0.83 | SRC (0.45) | METFGFR1KDRMEN1CDK2 | |
| SCHEMBL2114496 | 0.80 | LRRK2 (0.42) | FGFR1KDRSRCPDGFRBABL1 | |
| SCHEMBL1673441 | 0.79 | ALK (0.52) | METFGFR1KDRMEN1KMT2A | |
| SCHEMBL2117957 | 0.79 | MEN1 (0.46) | FGFR1KDRMEN1KMT2ASRC | |
| SCHEMBL393773 | 0.78 | TLK2 (0.48) | KDRAURKANTRK1RETKIT | |
| SCHEMBL4474309 | 0.77 | ALK (0.58) | MGAT2METFGFR1KDRMEN1 | |
| SCHEMBL3720888 | 0.77 | ALK (0.58) | MGAT2METFGFR1KDRMEN1 | |
| SCHEMBL2114212 | 0.75 | KDR (0.44) | FGFR1KDRCDK2SRCPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120094998-A1 | Oligomer-Protein Tyrosine Kinase Inhibitor Conjugates | NEKTAR THERAPEUTICS (US) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094998-A1 | Oligomer-Protein Tyrosine Kinase Inhibitor Conjugates | PTK2B, ERBB2, FRK | MGAT2 3418/4885MET 354/4885FGFR1 462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.