Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 10/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18368150 | 1.00 | RIPK1 (0.52) | RIPK1GAAEPHX2BRD4CREBBP | |
| SCHEMBL3485743 | 0.88 | GAA (0.57) | RIPK1GAAEPHX2IDO1MAPK10 | |
| SCHEMBL1561667 | 0.88 | GAA (0.57) | RIPK1GAAEPHX2IDO1MAPK10 | |
| SCHEMBL1561665 | 0.88 | GAA (0.57) | RIPK1GAAEPHX2IDO1MAPK10 | |
| SCHEMBL21307358 | 0.88 | EPHX2 (0.44) | RIPK1GAAEPHX2BRD4CREBBP | |
| SCHEMBL7986840 | 0.82 | BRD4 (0.48) | GAAEPHX2BRD4CREBBP | |
| SCHEMBL29264385 | 0.82 | BRD4 (0.48) | GAAEPHX2BRD4CREBBP | |
| SCHEMBL22048691 | 0.81 | ACACB (0.42) | RIPK1GAAEPHX2IDO1MAPK10 | |
| SCHEMBL5640963 | 0.80 | EPHX2 (0.56) | RIPK1GAAEPHX2 | |
| SCHEMBL1269023 | 0.80 | EPHX2 (0.56) | RIPK1GAAEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3508484-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2019-07-10 | — | — | EP | disclosed |