Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.38 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.36 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.36 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.36 |
| ▸ | ACACB | O00763 | 3/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | WNT1 | P04628 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24556782 | 0.88 | ABCB11 (0.38) | ABCB11SLCO1B1CYP4A11CYP4F2BMPR1B | |
| SCHEMBL22578295 | 0.85 | SLCO1B1 (0.55) | ABCB11SLCO1B1CYP4A11CYP4F2WNT1 | |
| SCHEMBL22463678 | 0.85 | SLCO1B1 (0.55) | ABCB11SLCO1B1CYP4A11CYP4F2WNT1 | |
| SCHEMBL22578294 | 0.85 | SLCO1B1 (0.55) | ABCB11SLCO1B1CYP4A11CYP4F2WNT1 | |
| SCHEMBL22576690 | 0.81 | SLCO1B1 (0.45) | ABCB11SLCO1B1CYP4A11CYP4F2ACACB | |
| SCHEMBL22577733 | 0.81 | SLCO1B1 (0.45) | ABCB11SLCO1B1CYP4A11CYP4F2ACACB | |
| SCHEMBL31212636 | 0.81 | SLCO1B1 (0.45) | ABCB11SLCO1B1CYP4A11CYP4F2ACACB | |
| SCHEMBL21157294 | 0.80 | NPC1 (0.39) | ABCB11SLCO1B1CYP4A11CYP4F2BMPR1B | |
| SCHEMBL30338659 | 0.80 | SLCO1B1 (0.62) | ABCB11SLCO1B1CYP4A11CYP4F2LPAR1 | |
| SCHEMBL21156725 | 0.80 | LPAR1 (0.37) | ABCB11SLCO1B1WNT1GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3728216-B1 | PYRAZOLE N-LINKED CARBAMOYL CYCLOHEXYL ACIDS AS LPA ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2023-09-06 | — | — | EP | disclosed |
| EP-3727589-B1 | CYCLOHEXYL ACID PYRAZOLE AZOLES AS LPA ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2022-06-29 | — | — | EP | disclosed |
| WO-2019126085-A1 | PYRAZOLE N-LINKED CARBAMOYL CYCLOHEXYL ACIDS AS LPA ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-06-27 | — | — | WO | disclosed |