Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19154290 | 0.86 | AR (0.36) | TTRFFAR1EPAS1ARKIF11 | |
| SCHEMBL14662604 | 0.84 | EPAS1 (0.44) | TTRFFAR1EPAS1ARKIF11 | |
| SCHEMBL15904332 | 0.83 | FFAR1 (0.49) | TTRFFAR1ARKIF11S1PR1 | |
| SCHEMBL19154082 | 0.81 | ROCK2 (0.41) | TTRFFAR1EPAS1ARKIF11 | |
| SCHEMBL875557 | 0.79 | EPAS1 (0.52) | TTRFFAR1EPAS1ARTLR8 | |
| SCHEMBL15813980 | 0.79 | AR (0.45) | EPAS1ARRXRARXRG | |
| SCHEMBL14661984 | 0.77 | TLR8 (0.40) | TTRFFAR1EPAS1ARKIF11 | |
| SCHEMBL14662159 | 0.73 | TTR (0.47) | TTREPAS1ARS1PR1S1PR3 | |
| SCHEMBL14656182 | 0.73 | TTR (0.47) | TTREPAS1CYP4F2CYP4A11ROCK2 | |
| SCHEMBL14656214 | 0.73 | TTR (0.51) | TTRS1PR1S1PR3CYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3172211-B1 | TRICYCLIC IMIDAZO-PYRIMIDINONE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY LP-PLA2 | GLAXOSMITHKLINE IP DEV LTD (GB) | 2019-07-03 | — | — | EP | disclosed |