Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 6/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19019335 | 0.82 | ALDH1A1 (0.41) | SMN1; SMN2ALDH1A1PIK3CDHPGDKMT2A | |
| SCHEMBL17520809 | 0.81 | ALDH1A1 (0.33) | ALDH1A1PIK3CDCYP2C19 | |
| SCHEMBL21017090 | 0.79 | HPGD (0.48) | SMN1; SMN2HTTALDH1A1PIK3CDHPGD | |
| SCHEMBL13328580 | 0.78 | EPHX1 (0.34) | SMN1; SMN2HTTALDH1A1PIK3CDGAA | |
| SCHEMBL28154673 | 0.77 | ALDH1A1 (0.41) | ALDH1A1L3MBTL1 | |
| SCHEMBL5568298 | 0.76 | HMGCR (0.35) | ALDH1A1PIK3CDCYP3A4CYP2C19CYP2C9 | |
| SCHEMBL15498405 | 0.76 | ALDH1A1 (0.64) | SMN1; SMN2HTTALDH1A1PIK3CDHPGD | |
| SCHEMBL13240049 | 0.76 | ALDH1A1 (0.44) | SMN1; SMN2HTTALDH1A1PIK3CDHPGD | |
| SCHEMBL1515479 | 0.75 | PIK3CD (0.41) | SMN1; SMN2HTTALDH1A1PIK3CDHPGD | |
| SCHEMBL19494993 | 0.75 | ALDH1A1 (0.33) | SMN1; SMN2ALDH1A1KMT2AMEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3172211-B1 | TRICYCLIC IMIDAZO-PYRIMIDINONE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY LP-PLA2 | GLAXOSMITHKLINE IP DEV LTD (GB) | 2019-07-03 | — | — | EP | disclosed |