Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.46 |
| ▸ | CHKA | P35790 | 3/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | NCF1 | P14598 | 1/20 | 0.40 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20071088 | 0.88 | CHKA (0.59) | TRPV6HRH3CHKAPIK3CDPIK3CA | |
| SCHEMBL23589183 | 0.86 | HRH3 (0.67) | TRPV6HRH3CD274PIK3CDPIK3CA | |
| SCHEMBL20148592 | 0.84 | HRH3 (0.53) | TRPV6HRH3CD274PIK3CDPIK3CA | |
| SCHEMBL20353469 | 0.82 | HRH3 (0.51) | TRPV6HRH3CD274KDM4E | |
| SCHEMBL18713082 | 0.81 | TRPV6 (0.57) | TRPV6HRH3CHKAPIK3CDPIK3CA | |
| SCHEMBL18713087 | 0.81 | TRPV6 (0.57) | TRPV6HRH3KDM4EJAK2JAK1 | |
| SCHEMBL20413614 | 0.80 | TRPV6 (0.56) | TRPV6HRH3CD274JAK2JAK1 | |
| SCHEMBL20353620 | 0.80 | TRPV6 (0.53) | TRPV6HRH3CD274JAK2JAK1 | |
| SCHEMBL20970845 | 0.78 | TRPV6 (0.52) | TRPV6HRH3JAK2JAK1JAK3 | |
| SCHEMBL18390583 | 0.78 | TRPV6 (0.54) | TRPV6HRH3KDM4EJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10555944-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | ELI LILLY AND COMPANY (US) | 2020-02-11 | — | — | US | disclosed |
| US-20190183886-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2019-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10555944-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | RET, ROR1, BRAF | TRPV6 4180/4885HRH3 1148/4885CD274 2514/4885 |
| US-20190183886-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, ROR1, BRAF | TRPV6 4180/4885HRH3 1148/4885CD274 2514/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.