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TRPV6

Transient receptor potential cation channel subfamily V member 6 · Q9H1D0 · TRPV6 on Sugi Atlas →

9,885 patent compounds predicted against TRPV6, 5,989 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Diphenyl Borinic Acid Diphenyl Borinic Acid (SCHEMBL40601) 1.00 7/20
SCHEMBL2412647 SCHEMBL2412647 0.93 7/20
SCHEMBL2406379 SCHEMBL2406379 0.82 7/20
SCHEMBL2406124 SCHEMBL2406124 0.78 7/20
SCHEMBL1138231 SCHEMBL1138231 0.70 7/20
SCHEMBL2411541 SCHEMBL2411541 0.64 7/20
SCHEMBL2399069 SCHEMBL2399069 0.54 7/20
SCHEMBL1003006 SCHEMBL1003006 1.00 6/20
SCHEMBL1138482 SCHEMBL1138482 0.80 6/20
SCHEMBL2407457 SCHEMBL2407457 0.74 6/20
SCHEMBL2405808 SCHEMBL2405808 0.72 6/20
SCHEMBL2408532 SCHEMBL2408532 0.62 6/20
SCHEMBL2400633 SCHEMBL2400633 0.58 6/20
SCHEMBL1204089 SCHEMBL1204089 0.58 6/20
SCHEMBL2408066 SCHEMBL2408066 0.56 6/20
SCHEMBL1204182 SCHEMBL1204182 0.53 6/20
SCHEMBL974659 SCHEMBL974659 0.52 6/20
SCHEMBL2406706 SCHEMBL2406706 1.00 5/20
SCHEMBL2398673 SCHEMBL2398673 0.54 5/20
SCHEMBL2406507 SCHEMBL2406507 0.54 5/20

Clinical trials — most relevant to TRPV6 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
TRPV Expression in Subjects With Sensitive Skin PHASE4UNKNOWN
Mechanisms of Capsaicin Treatment in Idiopathic Rhinitis Patients and Controls PHASE4COMPLETED
The Re-Prosper HF Study PHASE2/PHASE3COMPLETED
Botulinum Toxin Injections for Oral Neuropathic Pain PHASE3COMPLETED
Suzetrigine in Total Hip Arthroplasty PHASE3RECRUITING
Early Study on Tamoxifen Safety/Tolerability in Cystic Fibrosis Patients Unable to Use CFTR Modulators. PHASE2NOT_YET_RECRUITING
Effect of Botulinum Toxin A on Detrusor Overactivity and Renal Function in Chronic Spinal Cord Injured Patients PHASE2COMPLETED
Assessment of KM-001 - Safety, Tolerability, and Efficacy in Patients With PPPK1 or PC PHASE1COMPLETED
Study Designed to Evaluate Safety and Efficacy of 1% Topical Formulation of KM-001 on Type 1 Punctate Palmoplantar Keratoderma or Pachyonychia Congenita Diseases PHASE1COMPLETED
Do Acid Sensing Ion Channels Contribute to Heartburn? PHASE1COMPLETED
Mechanism of Human Cold Pain Perception - Involvement of TRPA1, TRPM8, Nav1.7 and Nav1.8 EARLY_PHASE1COMPLETED
Mechanisms of Human Heat Perception - Involvement of TRPA1, TRPV1 and TRPM3 EARLY_PHASE1COMPLETED
Menthol Stimulation of Brown Adipose Tissue in Humans: Aim 1 EARLY_PHASE1RECRUITING
Concentration of Receptors With Affinity for Cannabidiol and Cannabinol and the Effect on Chronic Orofacial Pain of Muscle Origin nanENROLLING_BY_INVITATION
The Natural History of TRPV4 Neuropathy nanRECRUITING
Relationship Between Polymorphisms of TRPV1 and KCC2 Gene in Children With Febrile Seizures nanCOMPLETED
Neurogenic Mechanisms in Burning Mouth Syndrome nanCOMPLETED
Identification of TRP Channels as New Potential Therapeutic Targets in Primary and Secondary Raynaud's Phenomenon. nanCOMPLETED
Qutenza 8% Capsaicin Topical System for the Treatment of Neuropathic Axial Lower Back Pain and Lumbosacral Radiculopathy nanENROLLING_BY_INVITATION
Factors Affecting Salt Intake in Young Adults nanUNKNOWN
Dissecting the Heterogeneity of Oral Cancer Pain nanUNKNOWN
Nutrition for Migraine Prevention nanCOMPLETED
Effect of Intraperitoneal Ropivacaine on Visceral Pain After Laparoscopic Gastrectomy nanUNKNOWN
A Study on the Mechanism of Cough Hypersensitivity nanUNKNOWN
Effects of Photobiomodulation on the Innate Immune System of Neonates and Infants With Bronchiolitis nanUNKNOWN
Defining TRPV4 Contribution of Schwann Cells to Oral Cancer Pain nanRECRUITING
An Investigation Into the Mechanism of Inhalation Cough Challenge nanCOMPLETED
Tumor Necrosis Factor Decreases Vitamin D Dependant Calcium Absorption nanCOMPLETED
Characterization of New Human Models of Non-histaminergic Itch and Their Interaction With the TRPM8 Receptor nanCOMPLETED
The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain. nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a TRPV6 binder may also engage these)

ProteinNameSimilarity
Q9R186 — 1.000 Q9R186 →
Q9XSM3 — 0.998 Q9XSM3 →
Q91WD2 — 0.998 Q91WD2 →
P69744 — 0.998 P69744 →
Q9JIP0 — 0.996 Q9JIP0 →
TRPV1 Transient receptor potential cation channel subfamily V member 1 0.995 landscape →
Q704Y3 — 0.992 Q704Y3 →
TRPV5 Transient receptor potential cation channel subfamily V member 5 0.992 landscape →
A0A1D5PXA5 — 0.992 A0A1D5PXA5 →
Q9ERZ8 — 0.992 Q9ERZ8 →
Q9EPK8 — 0.991 Q9EPK8 →
Q9WUD2 — 0.990 Q9WUD2 →
Q6RX08 — 0.989 Q6RX08 →
TRPV2 Transient receptor potential cation channel subfamily V member 2 0.989 landscape →
TRPV4 Transient receptor potential cation channel subfamily V member 4 0.988 landscape →
Q9WTR1 — 0.988 Q9WTR1 →
Q9MYV9 — 0.987 Q9MYV9 →
Q6R5A3 — 0.987 Q6R5A3 →
Q9QX29 — 0.987 Q9QX29 →
Q697L1 — 0.986 Q697L1 →
O35433 — 0.986 O35433 →
P48994 — 0.986 P48994 →
P19334 — 0.986 P19334 →
TRPC5 Short transient receptor potential channel 5 0.986 landscape →
Q9QUQ5 — 0.985 Q9QUQ5 →
Q38998 — 0.985 Q38998 →
TRPC1 Short transient receptor potential channel 1 0.985 landscape →
Q8K424 — 0.985 Q8K424 →
TRPV3 Transient receptor potential cation channel subfamily V member 3 0.985 landscape →
D3YWQ0 — 0.985 D3YWQ0 →