⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18713122 | 0.85 | — | — | |
| SCHEMBL12193289 | 0.77 | — | — | |
| SCHEMBL14155801 | 0.77 | ATM (0.34) | — | |
| SCHEMBL14410773 | 0.73 | LMNA (0.32) | — | |
| SCHEMBL20993573 | 0.71 | — | — | |
| SCHEMBL20993512 | 0.71 | — | — | |
| SCHEMBL13037117 | 0.71 | — | — | |
| SCHEMBL20069488 | 0.70 | — | — | |
| SCHEMBL12142225 | 0.70 | — | — | |
| SCHEMBL22959040 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10555944-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | ELI LILLY AND COMPANY (US) | 2020-02-11 | — | — | US | disclosed |
| US-20190183886-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2019-06-20 | — | — | US | disclosed |