Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20152356 | 0.88 | HPGD (0.54) | HPGDALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL20071790 | 0.82 | HPGD (0.58) | HPGDALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL20148734 | 0.79 | HPGD (0.54) | HPGDALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL23555144 | 0.77 | HPGD (0.52) | HPGDALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL108058 | 0.73 | HPGD (0.59) | HPGDALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6281941 | 0.69 | HPGD (0.69) | HPGDALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL108225 | 0.68 | ALDH1A1 (0.90) | HPGDALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL20160507 | 0.68 | RET (0.42) | HPGDALDH1A1KMT2ATSHRRET | |
| SCHEMBL18029393 | 0.68 | ALDH1A1 (0.72) | HPGDALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL18026605 | 0.68 | ALDH1A1 (0.67) | HPGDALDH1A1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190183886-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2019-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190183886-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, ROR1, BRAF | HPGD 3857/4885ALDH1A1 2868/4885CYP1A2 3812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.