SCHEMBL21160352

SCHEMBL21160352

C#Cc1c(C#N)ccc2ccccc12

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 3/20 0.47
CA2 P00918 3/20 0.47
ALDH1A1 P00352 5/20 0.41
KDM4E B2RXH2 4/20 0.41
CYP2A6 P11509 1/20 0.41
TSHR P16473 1/20 0.41
HSD17B10 Q99714 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
ANPEP P15144 1/20 0.39
MCL1 Q07820 1/20 0.39
AR P10275 1/20 0.39
HPRT1 P00492 1/20 0.38
IMPDH2 P12268 2/20 0.38
IMPDH1 P20839 2/20 0.38
CYP1A2 P05177 2/20 0.37
CYP2C19 P33261 1/20 0.37
MEN1 O00255 2/20 0.36
GAA P10253 2/20 0.36
MAPT P10636 2/20 0.36
KMT2A Q03164 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5431973 0.86 CYP2A6 (0.46) CA1CA2ALDH1A1CYP2A6TSHR
SCHEMBL31676618 0.86 CYP2A6 (0.46) CA1CA2ALDH1A1CYP2A6TSHR
SCHEMBL646163 0.86 CA1 (0.52) CA1CA2ALDH1A1KDM4ECYP2A6
Ethylene SCHEMBL27960904 0.82 CA1 (0.48) CA1CA2ALDH1A1KDM4ECYP2A6
SCHEMBL29065571 0.82 CA1 (0.48) CA1CA2ALDH1A1KDM4ECYP2A6
Anthracene SCHEMBL28261733 0.81 CA1 (0.47) CA1CA2ALDH1A1KDM4ECYP2A6
SCHEMBL3245559 0.81 CA1 (0.52) CA1CA2ALDH1A1KDM4ECYP2A6
SCHEMBL28241231 0.77 ANPEP (0.56) CA1CA2ALDH1A1KDM4ECYP2A6
SCHEMBL8828836 0.77 ANPEP (0.56) CA1CA2ALDH1A1KDM4ECYP2A6
SCHEMBL2745872 0.77 APP (0.41) CA2ALDH1A1KDM4ECYP2A6TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019117733-A1 THE USE OF ACETYLENE DERIVATIVES IN RUMINANTS PASTORAL GREENHOUSE GAS RESEARCH LTD (NZ) 2019-06-20 WO disclosed
CN-1265645-A Urokinase inhibitors ABBOTT LAB (US) 2000-09-06 CN disclosed