Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13904588 | 0.78 | CYP3A4 (0.39) | KDM4EALDH1A1RAB9AHSD17B10PAX8 | |
| SCHEMBL13904591 | 0.78 | CYP3A4 (0.39) | KDM4EALDH1A1RAB9AHSD17B10PAX8 | |
| SCHEMBL22088138 | 0.72 | PAX8 (0.48) | KDM4EALDH1A1RAB9AHSD17B10PAX8 | |
| SCHEMBL29394477 | 0.72 | PAX8 (0.48) | KDM4EALDH1A1RAB9AHSD17B10PAX8 | |
| SCHEMBL22088551 | 0.72 | PAX8 (0.48) | KDM4EALDH1A1RAB9AHSD17B10PAX8 | |
| SCHEMBL21162145 | 0.72 | PAX8 (0.48) | KDM4EALDH1A1RAB9AHSD17B10PAX8 | |
| SCHEMBL13904856 | 0.72 | PAX8 (0.48) | KDM4EALDH1A1RAB9AHSD17B10PAX8 | |
| SCHEMBL13347223 | 0.68 | KDM4E (0.43) | KDM4EALDH1A1RAB9AHSD17B10PAX8 | |
| SCHEMBL13153860 | 0.67 | PAX8 (0.45) | KDM4EALDH1A1RAB9AHSD17B10PAX8 | |
| SCHEMBL13271858 | 0.67 | PAX8 (0.45) | KDM4EALDH1A1RAB9AHSD17B10PAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020117894-A1 | ISOCARBOSTYRIL ALKALOIDS AND FUNCTIONALIZATION THEREOF | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2020-06-11 | — | — | WO | disclosed |
| US-10336737-B2 | Metal catalyzed dearomative 1,2-carboamination | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2019-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10336737-B2 | Metal catalyzed dearomative 1,2-carboamination | DNTT, DIMT1, NMT1 | KDM4E 2493/4885ALDH1A1 1480/4885RAB9A 3494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.