Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 5/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.38 |
| ▸ | AKT2 | P31751 | 5/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.36 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.36 |
| ▸ | GRK5 | P34947 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 2/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2113982 | 0.94 | KDR (0.47) | KDRPDGFRBFGFR1EGFRSRC | |
| SCHEMBL2113935 | 0.92 | LRRK2 (0.42) | LRRK2RAF1KDRPDGFRBFGFR1 | |
| SCHEMBL2114116 | 0.89 | LRRK2 (0.42) | LRRK2RAF1KDRPDGFRBFGFR1 | |
| SCHEMBL2116323 | 0.89 | KDR (0.45) | KDRPDGFRBFGFR1EGFRSRC | |
| SCHEMBL2117973 | 0.86 | PDGFRB (0.42) | LRRK2KDRPDGFRBFGFR1EGFR | |
| SCHEMBL2117924 | 0.82 | RAF1 (0.39) | LRRK2RAF1KDRPDGFRBFGFR1 | |
| SCHEMBL2114117 | 0.82 | KDR (0.46) | KDRPDGFRBFGFR1EGFRSRC | |
| SCHEMBL2114496 | 0.79 | LRRK2 (0.42) | LRRK2RAF1KDRPDGFRBFGFR1 | |
| SCHEMBL2113662 | 0.79 | MEN1 (0.40) | LRRK2KDRPDGFRBFGFR1EGFR | |
| SCHEMBL2117534 | 0.78 | CCNB2 (0.42) | RAF1KDRPDGFRBFGFR1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120094998-A1 | Oligomer-Protein Tyrosine Kinase Inhibitor Conjugates | NEKTAR THERAPEUTICS (US) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094998-A1 | Oligomer-Protein Tyrosine Kinase Inhibitor Conjugates | PTK2B, ERBB2, FRK | LRRK2 580/4885RAF1 238/4885KDR 395/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.