Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | DHCR7 | Q9UBM7 | 3/20 | 0.38 |
| ▸ | EBP | Q15125 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19853574 | 0.87 | KDM4E (0.47) | KDM4EALDH1A1ALOX15POLBKMT2A | |
| SCHEMBL14175056 | 0.87 | KDM4E (0.47) | KDM4EALDH1A1ALOX15POLBKMT2A | |
| SCHEMBL446115 | 0.87 | CYP2D6 (0.34) | KDM4EALDH1A1ALOX15POLBCYP2D6 | |
| SCHEMBL2117596 | 0.86 | ALDH1A1 (0.37) | KDM4EALDH1A1ALOX15POLBKMT2A | |
| SCHEMBL18411956 | 0.84 | KDM4E (0.48) | KDM4EALDH1A1ALOX15POLBKMT2A | |
| SCHEMBL18976856 | 0.84 | KDM4E (0.53) | KDM4EALDH1A1ALOX15POLBKMT2A | |
| SCHEMBL14355433 | 0.84 | KDM4E (0.53) | KDM4EALDH1A1ALOX15POLBKMT2A | |
| SCHEMBL26118274 | 0.84 | KDM4E (0.47) | KDM4EALDH1A1ALOX15POLBKMT2A | |
| SCHEMBL82615 | 0.84 | KDM4E (0.47) | KDM4EALDH1A1ALOX15POLBKMT2A | |
| SCHEMBL21931367 | 0.80 | KDM4E (0.47) | KDM4EALDH1A1ALOX15POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158652-B2 | 1-Difluoromethyl-5-{4-[3-(1-piperidinyl)propoxy]phenyl}-2(1H)-pyridone; compounds act as histamine-H3 receptor antagonistic substances or inverse-agonistic substances; useful as preventives or remedies for various circular system diseases, nervous system diseases, metabolic system diseases | MSD K.K. (JP) | 2012-04-17 | — | — | US | disclosed |
| US-20080269287-A1 | Substituted Pyridone Derivative | MSD K.K. (JP) | 2008-10-30 | — | — | US | disclosed |
| EP-1820797-A1 | SUBSTITUTED PYRIDONE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-08-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269287-A1 | Substituted Pyridone Derivative | HRH3, HRH4, HRH1 | KDM4E 368/4885ALDH1A1 596/4885ALOX15 449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.