SCHEMBL21163181

SCHEMBL21163181

CC(C)(C)OC(=O)N1CCC[C@H]1c1nc(C2CCCCCCCC2)no1

nearest known ligand 0.50

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.50
TSHR P16473 4/20 0.47
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
L3MBTL1 Q9Y468 2/20 0.47
CPT1A P50416 2/20 0.45
CPT2 P23786 1/20 0.45
DPP4 P27487 1/20 0.44
PREP P48147 1/20 0.44
DPP8 Q6V1X1 1/20 0.44
DPP9 Q86TI2 1/20 0.44
DPP7 Q9UHL4 1/20 0.44
GRM5 P41594 1/20 0.43
HSD11B1 P28845 1/20 0.43
LMNA P02545 2/20 0.43
MAPT P10636 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
PDE8B O95263 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21163830 0.91 CPT1A (0.55) ALDH1A1TSHRMEN1KMT2AL3MBTL1
SCHEMBL4954716 0.89 ALDH1A1 (0.48) ALDH1A1TSHRMEN1KMT2AL3MBTL1
SCHEMBL4954721 0.89 ALDH1A1 (0.48) ALDH1A1TSHRMEN1KMT2AL3MBTL1
SCHEMBL4954599 0.88 DPP4 (0.53) ALDH1A1TSHRMEN1KMT2AL3MBTL1
SCHEMBL4954592 0.88 DPP4 (0.53) ALDH1A1TSHRMEN1KMT2AL3MBTL1
SCHEMBL4956804 0.85 DPP4 (0.55) ALDH1A1TSHRMEN1KMT2AL3MBTL1
SCHEMBL4956797 0.85 DPP4 (0.55) ALDH1A1TSHRMEN1KMT2AL3MBTL1
SCHEMBL8272731 0.83 ALDH1A1 (0.44) ALDH1A1TSHRMEN1KMT2AL3MBTL1
SCHEMBL13805609 0.83 ALDH1A1 (0.54) ALDH1A1TSHRMEN1KMT2AL3MBTL1
SCHEMBL14641475 0.82 ALDH1A1 (0.50) ALDH1A1TSHRMEN1KMT2AL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2906553-B1 OREXIN RECEPTOR ANTAGONISTS WHICH ARE [ORTHO BI (HETERO )ARYL]-[2-(META BI (HETERO)ARYL)-PYRROLIDIN-1-YL]-METHANONE DERIVATIVES IDORSIA PHARMACEUTICALS LTD (CH) 2019-06-26 EP disclosed