Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 2/20 | 0.47 |
| ▸ | F2R | P25116 | 9/20 | 0.45 |
| ▸ | HRAS | P01112 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12894978 | 0.88 | TOP1 (0.48) | TOP1F2RHRASESR1ESR2 | |
| SCHEMBL24388700 | 0.85 | TOP1 (0.49) | TOP1F2RHRASESR1ESR2 | |
| SCHEMBL13117928 | 0.82 | TOP1 (0.57) | TOP1F2RHRASESR1ESR2 | |
| SCHEMBL7786957 | 0.80 | ALDH1A1 (0.47) | TOP1F2RHRASESR1ESR2 | |
| SCHEMBL7786959 | 0.80 | TP53 (0.46) | TOP1F2RHRASESR1ESR2 | |
| SCHEMBL6205160 | 0.78 | TP53 (0.44) | TOP1F2RMAPTKDM4EALDH1A1 | |
| SCHEMBL31614481 | 0.77 | TOP1 (0.57) | TOP1HRASESR1ESR2MAPT | |
| SCHEMBL23626915 | 0.75 | HRAS (0.46) | TOP1HRASESR1ESR2MAPT | |
| SCHEMBL6177782 | 0.74 | TOP1 (0.41) | TOP1F2RHRASESR1ESR2 | |
| SCHEMBL6181086 | 0.74 | TOP1 (0.41) | TOP1F2RHRASESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10350300-B2 | Alkylating agent for alkylating target with driver oncogene mutation | CHIBA PREFECTURE (JP) | 2019-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10350300-B2 | Alkylating agent for alkylating target with driver oncogene mutation | KRAS, TP53, MYC | TOP1 968/4885F2R 4795/4885HRAS 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.