Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.71 |
| ▸ | HPGD | P15428 | 3/20 | 0.71 |
| ▸ | RAB9A | P51151 | 6/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | NPC1 | O15118 | 4/20 | 0.64 |
| ▸ | USP14 | P54578 | 8/20 | 0.61 |
| ▸ | USP7 | Q93009 | 3/20 | 0.61 |
| ▸ | USP5 | P45974 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19501159 | 0.93 | SMN1; SMN2 (0.65) | SMN1; SMN2HPGDRAB9APOLBNPC1 | |
| SCHEMBL17949743 | 0.91 | SMN1; SMN2 (0.73) | SMN1; SMN2HPGDRAB9APOLBNPC1 | |
| SCHEMBL6922889 | 0.91 | SMN1; SMN2 (0.62) | SMN1; SMN2HPGDRAB9APOLBNPC1 | |
| SCHEMBL19501674 | 0.88 | SMN1; SMN2 (0.70) | SMN1; SMN2HPGDRAB9APOLBNPC1 | |
| SCHEMBL19501661 | 0.88 | SMN1; SMN2 (0.67) | SMN1; SMN2HPGDRAB9APOLBNPC1 | |
| SCHEMBL17949731 | 0.87 | SMN1; SMN2 (0.83) | SMN1; SMN2HPGDRAB9APOLBNPC1 | |
| SCHEMBL19749176 | 0.87 | SMN1; SMN2 (0.65) | SMN1; SMN2HPGDRAB9APOLBNPC1 | |
| SCHEMBL19501259 | 0.85 | SMN1; SMN2 (0.72) | SMN1; SMN2HPGDRAB9APOLBNPC1 | |
| SCHEMBL21165107 | 0.85 | SMN1; SMN2 (0.57) | SMN1; SMN2HPGDRAB9APOLBNPC1 | |
| SCHEMBL6923352 | 0.85 | SMN1; SMN2 (0.57) | SMN1; SMN2HPGDRAB9APOLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10351568-B2 | Compositions and methods for enhancing proteasome activity | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10351568-B2 | Compositions and methods for enhancing proteasome activity | PSMG3, PSME3, PSMB11 | SMN1; SMN2 307/4885HPGD 4170/4885RAB9A 2509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.