Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13119696 | 0.82 | KMT2A (0.70) | SMN1; SMN2ALDH1A1HTTKMT2AKDM4E | |
| SCHEMBL21144053 | 0.81 | SMN1; SMN2 (0.64) | SMN1; SMN2ALDH1A1HTTKMT2AADORA2A | |
| SCHEMBL21143745 | 0.81 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1HTTKMT2AADORA2A | |
| SCHEMBL21144128 | 0.81 | GBA1 (0.49) | SMN1; SMN2ALDH1A1HTTKMT2AADORA2A | |
| SCHEMBL19708837 | 0.80 | SMN1; SMN2 (0.62) | SMN1; SMN2ALDH1A1HTTKMT2AADORA2A | |
| SCHEMBL19687495 | 0.79 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1HTTKMT2AADORA2A | |
| SCHEMBL4213091 | 0.77 | KMT2A (0.70) | SMN1; SMN2ALDH1A1HTTKMT2AADORA2A | |
| SCHEMBL21144344 | 0.76 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1HTTKMT2AADORA2A | |
| SCHEMBL21144023 | 0.76 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1HTTKMT2AADORA2A | |
| SCHEMBL11454994 | 0.76 | SMN1; SMN2 (1.00) | SMN1; SMN2ALDH1A1HTTKMT2AADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10774064-B2 | Potassium channel modulators | CADENT THERAPEUTICS, INC. (US) | 2020-09-15 | — | — | US | disclosed |
| US-20190218200-A1 | POTASSIUM CHANNEL MODULATORS | NOVARTIS AG (CH) | 2019-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10774064-B2 | Potassium channel modulators | KCNJ11, KCNJ2, KCNJ1 | SMN1; SMN2 1109/4885ALDH1A1 1320/4885HTT 1384/4885 |
| US-20190218200-A1 | POTASSIUM CHANNEL MODULATORS | KCNJ11, KCNJ2, KCNJ1 | SMN1; SMN2 1109/4885ALDH1A1 1320/4885HTT 1384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.