Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | KLK1 | P06870 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 5/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21167570 | 0.88 | KDR (0.41) | KDRNPC1HSPA5METHDAC6 | |
| SCHEMBL21167592 | 0.88 | NPC1 (0.42) | KDRNPC1KLKB1KLK1MET | |
| SCHEMBL24591083 | 0.86 | KDR (0.39) | KDRNPC1METHDAC6AURKA | |
| SCHEMBL21167737 | 0.86 | NPC1 (0.41) | KDRNPC1HSPA5KLKB1KLK1 | |
| SCHEMBL21167575 | 0.86 | NPC1 (0.41) | KDRNPC1KLKB1KLK1MET | |
| SCHEMBL21167629 | 0.85 | NPC1 (0.44) | KDRNPC1HSPA5KLKB1KLK1 | |
| SCHEMBL21167674 | 0.85 | AURKA (0.40) | KDRNPC1HSPA5KLKB1KLK1 | |
| SCHEMBL21167621 | 0.85 | NPC1 (0.40) | KDRNPC1KLKB1KLK1MET | |
| SCHEMBL22475673 | 0.84 | KDR (0.40) | KDRNPC1HSPA5METHDAC6 | |
| SCHEMBL21167525 | 0.83 | BRAF (0.41) | KDRNPC1HSPA5KLKB1KLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3795573-B1 | CERTAIN TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR | HUTCHISON MEDIPHARMA LTD (CN) | 2022-07-06 | — | — | EP | disclosed |
| EP-3511330-B1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | HUTCHISON MEDIPHARMA LTD (CN) | 2020-09-30 | — | — | EP | disclosed |
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |