Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.34 |
| ▸ | AURKA | O14965 | 2/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21167570 | 0.89 | KDR (0.41) | KDRNPC1HDAC6FLT1MET | |
| SCHEMBL22475819 | 0.86 | NPC1 (0.43) | KDRNPC1HDAC6FLT1SYK | |
| SCHEMBL21167568 | 0.85 | KDR (0.40) | KDRNPC1HDAC6FLT1MET | |
| SCHEMBL21167656 | 0.84 | KDR (0.40) | KDRNPC1HDAC6METAURKA | |
| SCHEMBL22475999 | 0.84 | IGF1R (0.41) | KDRNPC1HDAC6SYKIGF1R | |
| SCHEMBL21167733 | 0.82 | NPC1 (0.42) | KDRNPC1HDAC6FLT1SYK | |
| SCHEMBL24591083 | 0.80 | KDR (0.39) | KDRNPC1HDAC6FLT1MET | |
| SCHEMBL22475874 | 0.78 | MET (0.46) | KDRNPC1HDAC6FLT1MET | |
| SCHEMBL21167726 | 0.77 | SYK (0.40) | KDRNPC1HDAC6SYKAURKA | |
| SCHEMBL22475963 | 0.77 | KDR (0.43) | KDRNPC1SYKIGF1REGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3511330-B1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | HUTCHISON MEDIPHARMA LTD (CN) | 2020-09-30 | — | — | EP | disclosed |