Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 7/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | AURKA | O14965 | 3/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | LDHA | P00338 | 1/20 | 0.34 |
| ▸ | LDHB | P07195 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22475817 | 0.90 | CSF1R (0.45) | CSF1RMAPK1AURKBFGFR3FGFR1 | |
| SCHEMBL21167614 | 0.87 | CSF1R (0.42) | CSF1RMAPK1AURKBMAP4K1 | |
| SCHEMBL21167411 | 0.87 | CSF1R (0.41) | CSF1RFGFR3FGFR1FGFR2KDR | |
| SCHEMBL21167440 | 0.86 | CSF1R (0.42) | CSF1RFGFR3FGFR1FGFR2KDR | |
| SCHEMBL24591027 | 0.84 | CSF1R (0.39) | CSF1RFGFR3FGFR1FGFR2LDHA | |
| SCHEMBL21167328 | 0.81 | MAPK1 (0.36) | CSF1RMAPK1AURKBFGFR2LDHA | |
| SCHEMBL24591047 | 0.80 | CSF1R (0.37) | CSF1RMAPK1AURKAAURKBFGFR3 | |
| SCHEMBL22475672 | 0.79 | CSF1R (0.41) | CSF1RMAPK1FGFR3FGFR1FGFR2 | |
| SCHEMBL22475803 | 0.78 | SYK (0.35) | CSF1RFGFR3FGFR1FGFR2KDR | |
| SCHEMBL24591126 | 0.78 | LRRK2 (0.36) | CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |