Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 6/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 6/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 3/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.34 |
| ▸ | KDR | P35968 | 3/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21167439 | 0.90 | SYK (0.37) | CSF1RSYKIKBKETBK1FEN1 | |
| SCHEMBL22475903 | 0.90 | SYK (0.37) | CSF1RSYKIKBKETBK1FEN1 | |
| SCHEMBL21167411 | 0.89 | CSF1R (0.41) | CSF1RSYKIKBKETBK1FEN1 | |
| SCHEMBL21167672 | 0.86 | CSF1R (0.56) | CSF1RFGFR1FGFR2FGFR3KDR | |
| SCHEMBL24591027 | 0.84 | CSF1R (0.39) | CSF1RTYRO3PIK3CDPIK3CGFGFR1 | |
| SCHEMBL21167558 | 0.80 | CSF1R (0.41) | CSF1RSYKIKBKETBK1FEN1 | |
| SCHEMBL21167519 | 0.80 | IKBKE (0.45) | CSF1RSYKIKBKETBK1FEN1 | |
| SCHEMBL22475803 | 0.80 | SYK (0.35) | CSF1RSYKFEN1FGFR1FGFR2 | |
| SCHEMBL22475672 | 0.79 | CSF1R (0.41) | CSF1RTYRO3PIK3CDPIK3CAPIK3CG | |
| SCHEMBL21167328 | 0.78 | MAPK1 (0.36) | CSF1RSYKIKBKETBK1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |