Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 6/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22475819 | 0.90 | NPC1 (0.43) | NPC1SYKKDRHDAC6FLT1 | |
| SCHEMBL21167731 | 0.88 | NPC1 (0.43) | NPC1SYKKDRHDAC6RAB9A | |
| SCHEMBL22475714 | 0.86 | BACE1 (0.41) | NPC1SYKKDRRAB9ABACE1 | |
| SCHEMBL21167728 | 0.84 | NPC1 (0.43) | NPC1SYKKDRHDAC6RAB9A | |
| SCHEMBL22475999 | 0.82 | IGF1R (0.41) | NPC1SYKKDRHDAC6 | |
| SCHEMBL22475673 | 0.82 | KDR (0.40) | NPC1SYKKDRHDAC6FLT1 | |
| SCHEMBL21167726 | 0.81 | SYK (0.40) | NPC1SYKKDRHDAC6BACE1 | |
| SCHEMBL22475963 | 0.79 | KDR (0.43) | NPC1SYKKDR | |
| SCHEMBL21167658 | 0.77 | NPC1 (0.45) | NPC1SYKKDRHDAC6FLT1 | |
| SCHEMBL24591152 | 0.76 | NPC1 (0.43) | NPC1SYKKDRHDAC6FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |