Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 8/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 8/20 | 0.35 |
| ▸ | KDR | P35968 | 7/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.34 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21167690 | 0.90 | MET (0.41) | METKITEGFRFGFR1FGFR3 | |
| SCHEMBL21167834 | 0.87 | MET (0.39) | METKITEGFRFGFR1FGFR3 | |
| SCHEMBL24591101 | 0.86 | MET (0.38) | METKITEGFRFGFR1FGFR3 | |
| SCHEMBL21167664 | 0.85 | EGFR (0.40) | METKITEGFRFGFR1FGFR3 | |
| SCHEMBL14378441 | 0.77 | MET (0.59) | METFGFR1FGFR3KDRFGFR2 | |
| SCHEMBL12483014 | 0.74 | MET (0.73) | METCYP2C9PDE3BPDE3APDE10A | |
| SCHEMBL22475773 | 0.73 | MET (0.43) | METFGFR1FGFR3FGFR2FEN1 | |
| SCHEMBL21167339 | 0.73 | MET (0.43) | METEGFRFGFR1FGFR3KDR | |
| SCHEMBL21167343 | 0.72 | MET (0.44) | METKITEGFRKDRFEN1 | |
| SCHEMBL22475890 | 0.71 | MET (0.43) | METKITEGFRFEN1IKBKE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3795573-B1 | CERTAIN TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR | HUTCHISON MEDIPHARMA LTD (CN) | 2022-07-06 | — | — | EP | disclosed |
| EP-3511330-B1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | HUTCHISON MEDIPHARMA LTD (CN) | 2020-09-30 | — | — | EP | disclosed |
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |