Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | CBLB | Q13191 | 1/20 | 0.31 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.31 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.31 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6468289 | 0.80 | DYRK1A (0.44) | DYRK1AMETPCSK9SCN5ATGFBR1 | |
| SCHEMBL16848813 | 0.77 | DYRK1A (0.41) | DYRK1AKDM4ETP53METPCSK9 | |
| SCHEMBL3347070 | 0.77 | DYRK1A (0.44) | DYRK1AMETPCSK9SCN5ATGFBR1 | |
| SCHEMBL2177217 | 0.77 | DYRK1A (0.47) | DYRK1AMETPCSK9SCN5ATGFBR1 | |
| SCHEMBL23529908 | 0.77 | DYRK1A (0.44) | DYRK1AKDM4EMETPCSK9SCN5A | |
| SCHEMBL7481486 | 0.76 | DYRK1A (0.41) | DYRK1AKDM4EMETPCSK9SCN5A | |
| SCHEMBL21368088 | 0.76 | KDM4E (0.47) | KDM4ETP53CYP2A6CYP3A4ADRB2 | |
| SCHEMBL5872614 | 0.73 | KCNH2 (0.51) | DYRK1AMETSCN5ATGFBR1 | |
| SCHEMBL13073615 | 0.73 | PCSK9 (0.44) | DYRK1APCSK9SCN5ATGFBR1PIK3CD | |
| SCHEMBL3347107 | 0.72 | DYRK1A (0.41) | DYRK1AMETPCSK9SCN5ATGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3795573-B1 | CERTAIN TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR | HUTCHISON MEDIPHARMA LTD (CN) | 2022-07-06 | — | — | EP | disclosed |
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |